DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dop1R2 and 5-HT2B

DIOPT Version :10

Sequence 1:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster
Sequence 2:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster


Alignment Length:979 Identity:180/979 - (18%)
Similarity:257/979 - (26%) Gaps:515/979 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 ISEDVYFYFNGL--------PTSTELVL-------NATTSATSATLSPAMVATGGGGTTTPEPDL 97
            :.||||......        .:|..|||       ..|.:|||......:......|..|    :
  Fly     1 MEEDVYASLGAYNDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNAT----I 61

  Fly    98 SEFLEALP---NDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGL 159
            |...|.:|   |:...|||.:.:  ..|..||.||.||:..||.|...||||:.|||:.|.:|.:
  Fly    62 SATFEDVPFDANNYWALLALVLV--LGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAV 124

  Fly   160 VVMPFSALYEVLENTWF-FGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTV 223
            :|||...|  .|...:| .|::.|..|..|||||.||||::||.||:|||.::..|..:....|.
  Fly   125 LVMPLGIL--TLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTR 187

  Fly   224 KRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFT 288
            :|....|..||:.|.|:|.|..:.:.......:....|...:.: |.:..|.:.||:||.||:.|
  Fly   188 RRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPV-YKLVGSIVCFYIPLGVMLLT 251

  Fly   289 YCRIYRAAVIQTRSLKIGTKQVL----MASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGG 349
            ||...|....|.::|..|.:...    .|||.|.....:.|..|.|.....          |.|.
  Fly   252 YCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKP----------GPGN 306

  Fly   350 GGSLSHSHS-------------------------------------------------------- 358
            ..|:.|:||                                                        
  Fly   307 ASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSST 371

  Fly   359 -----------------------------HSHHHHHNH-----------------------GGGT 371
                                         |...|||||                       |..|
  Fly   372 TGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLST 436

  Fly   372 TT--------------------------------------------------------------S 374
            ||                                                              .
  Fly   437 TTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVE 501

  Fly   375 TP-----------------------------EEPDDE---------------------------- 382
            ||                             ::.|||                            
  Fly   502 TPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQK 566

  Fly   383 ------------------------------PLS-------------------------------- 385
                                          ||.                                
  Fly   567 AKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEME 631

  Fly   386 ---------------------------------------ALHNNG-------------------- 391
                                                   :.||.|                    
  Fly   632 LLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPC 696

  Fly   392 ------------------LARHRHMGKNFS----------------------------------- 403
                              .:|||..|.:|.                                   
  Fly   697 PGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNM 761

  Fly   404 --------------------------------------LSRKLAKFAK----EKKAAKTLGIVMG 426
                                                  :||..::..:    |:||.|.||:|..
  Fly   762 NYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFF 826

  Fly   427 VFIICWLPFFVVNLLSGFCIECIEHEEIVS----AIVTWLGWINSCMNPVIYACWSRDFRRAFVR 487
            .|:|.|.||||:|||...|.||   ||.:|    .:|||||:.:|.:||:.|..:::.||:||.:
  Fly   827 TFVILWSPFFVLNLLPTVCAEC---EERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKK 888

  Fly   488 LLCMCCPRKIRRKYQPTMR---SKSQCHVAAAMVAASTSFGYHSVNQID--------RTLMXRQL 541
            :| :|       :|..|..   |:.|..|....:..:|    |....:|        |.:: |.:
  Fly   889 VL-LC-------RYSSTSAWRPSRXQTPVKPGKLKTNT----HKCASVDFQDSTAPVRGVLKRSV 941

  Fly   542 SSCS 545
            :..|
  Fly   942 AVAS 945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R2NP_001263072.1 7tmA_Dop1R2-like 122..485 CDD:320195 144/814 (18%)
TM helix 2 143..169 CDD:320195 13/25 (52%)
TM helix 3 182..212 CDD:320195 18/29 (62%)
TM helix 4 224..246 CDD:320195 8/21 (38%)
TM helix 5 266..295 CDD:320195 11/28 (39%)
TM helix 6 297..442 CDD:320195 59/591 (10%)
TM helix 7 453..478 CDD:320195 11/28 (39%)
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 71/197 (36%)
TM helix 1 75..101 CDD:320433 10/27 (37%)
TM helix 2 108..134 CDD:320433 13/27 (48%)
TM helix 3 146..176 CDD:320433 18/29 (62%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 11/29 (38%)
7tm_GPCRs <799..893 CDD:475119 40/104 (38%)
TM helix 6 818..840 CDD:410628 11/21 (52%)
TM helix 7 854..879 CDD:410628 9/24 (38%)

Return to query results.
Submit another query.