DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and mAChR-B

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	841	Identity:	180/841 - (21%)
Similarity:	293/841 - (34%)	Gaps:	256/841 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SFFGSYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFL-EAL 104
            |.|.|:.::|.:.:|.|....:|.|:|.....::.           ||.|.:.....||.| ..|
  Fly    72 SDFNSWPVNEQLQWYRNFDVNNTNLLLAVRNQSSD-----------GGSTMSGSSSDSEILGPVL 125

  Fly   105 PN----DRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFS 165
            |.    ..:.:...|.:....||.||.||:||.|.:|.:...:||||.|||..|.|:|.|.|||.
  Fly   126 PPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFY 190

  Fly   166 ALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLI 230
            .:| ||:..|..|...||:|.|:|......|...:.:|::|||.::.....|....|..|...::
  Fly   191 TIY-VLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMV 254

  Fly   231 AAVWICSSAISFPAIVWWR---AARDGEMPAYKCTFTEHLGYLVFSST--ISFYLPLLVMVFT-Y 289
            ...||..:.:.|.:|..|.   ..|| .:|. :|. .:.|...:|::.  |.:|...|:::|. |
  Fly   255 TITWIIPALLFFISIFGWEHFTGKRD-LLPG-QCA-VQFLKDPIFNTALIIGYYWTTLIVLFVLY 316

  Fly   290 CRIYRAAV-IQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSL 353
            ..||:.|. :|.||   ..||                    |..|:.|:...|...|..|
  Fly   317 AGIYKTAYDMQKRS---EAKQ--------------------RKMQSMVALSAGAMSGMAG----- 353

  Fly   354 SHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAA 418
                       |..|.|..                                         |:|..
  Fly   354 -----------HAAGIGVI-----------------------------------------EEKIL 366

  Fly   419 KTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSC--MNPVIYAC----- 476
            ||...:.|                       :..::.||..|.:..::..  .||:..|.
  Fly   367 KTKVELAG-----------------------DQTDLDSACTTVIKRLSGSGQANPLAVATEEVEK 408

  Fly   477 WSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFGY-----HSVNQIDRTL 536
            .:.:.|||        ...||:.:     ..|.:..|.|.....|:|..:     .||||..:.:
  Fly   409 MTPEQRRA--------SAAKIQEE-----AKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLI 460

  Fly   537 MXRQLSSCSTCSGGSNCGGSRSA----------------------------HHQHHSSGTATPSS 573
            . ::|::....|......|:::|                            |.|||.:  .:|..
  Fly   461 TQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHN--QSPLQ 523

  Fly   574 SQRSCTRCQSFHRH------HHRSRRRSSGMQMRGDYNSTTAVNSALAK--TIVTISAPPVAAAS 630
            ..:|....:|.|.|      ||:..:......:.....::.:..|.:|:  .:|.:||||....:
  Fly   524 RAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNT 588

  Fly   631 ASSLHLGVGGRPSSVSTLTIAS--VPPTLSGSGSPGGSVSGATTPLAPSLKALTPGPSNSSGHH- 692
            :..|      .|..::.:.:.|  |...|..:..|........|||:........|  ||||:.
  Fly   589 SDPL------SPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFG--NSSGNSE 645

  Fly   693 ----VSFMPMTGMKRLRSSNASLGSPNGIISTVAGADTTSAPSLIDASEDQVQMR---------- 743
                ...|..:.::.:..|:|.|.|        ..|::|::|:      |.||.:
  Fly   646 LALTYDLMTNSELRYMDESSAMLAS--------VTANSTTSPN------DSVQGKPPVLPPPPPA 696

  Fly   744 -------NQHRILEQCQSVQSQITTLGDVEDDDEEVSDSESESVGLALVVTTPQLESQPVE 797
                   |.::.|.|..| |:|                |.|:|:.|.|.....|.:||.:|
  Fly   697 RRNPPKSNLNQSLSQTPS-QNQ----------------SPSQSLSLNLNPNHNQSQSQSIE 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	59/177 (33%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	83/357 (23%)
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	66/217 (30%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	64/212 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840