DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop1R2 and mAChR-B

DIOPT Version :10

Sequence 1:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster
Sequence 2:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster


Alignment Length:841 Identity:180/841 - (21%)
Similarity:293/841 - (34%) Gaps:256/841 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 SFFGSYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFL-EAL 104
            |.|.|:.::|.:.:|.|....:|.|:|.....::.           ||.|.:.....||.| ..|
  Fly    72 SDFNSWPVNEQLQWYRNFDVNNTNLLLAVRNQSSD-----------GGSTMSGSSSDSEILGPVL 125

  Fly   105 PN----DRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFS 165
            |.    ..:.:...|.:....||.||.||:||.|.:|.:...:||||.|||..|.|:|.|.|||.
  Fly   126 PPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFY 190

  Fly   166 ALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLI 230
            .:| ||:..|..|...||:|.|:|......|...:.:|::|||.::.....|....|..|...::
  Fly   191 TIY-VLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMV 254

  Fly   231 AAVWICSSAISFPAIVWWR---AARDGEMPAYKCTFTEHLGYLVFSST--ISFYLPLLVMVFT-Y 289
            ...||..:.:.|.:|..|.   ..|| .:|. :|. .:.|...:|::.  |.:|...|:::|. |
  Fly   255 TITWIIPALLFFISIFGWEHFTGKRD-LLPG-QCA-VQFLKDPIFNTALIIGYYWTTLIVLFVLY 316

  Fly   290 CRIYRAAV-IQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSL 353
            ..||:.|. :|.||   ..||                    |..|:.|:...|...|..|     
  Fly   317 AGIYKTAYDMQKRS---EAKQ--------------------RKMQSMVALSAGAMSGMAG----- 353

  Fly   354 SHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAA 418
                       |..|.|..                                         |:|..
  Fly   354 -----------HAAGIGVI-----------------------------------------EEKIL 366

  Fly   419 KTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSC--MNPVIYAC----- 476
            ||...:.|                       :..::.||..|.:..::..  .||:..|.     
  Fly   367 KTKVELAG-----------------------DQTDLDSACTTVIKRLSGSGQANPLAVATEEVEK 408

  Fly   477 WSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFGY-----HSVNQIDRTL 536
            .:.:.|||        ...||:.:     ..|.:..|.|.....|:|..:     .||||..:.:
  Fly   409 MTPEQRRA--------SAAKIQEE-----AKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLI 460

  Fly   537 MXRQLSSCSTCSGGSNCGGSRSA----------------------------HHQHHSSGTATPSS 573
            . ::|::....|......|:::|                            |.|||.:  .:|..
  Fly   461 TQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHN--QSPLQ 523

  Fly   574 SQRSCTRCQSFHRH------HHRSRRRSSGMQMRGDYNSTTAVNSALAK--TIVTISAPPVAAAS 630
            ..:|....:|.|.|      ||:..:......:.....::.:..|.:|:  .:|.:||||....:
  Fly   524 RAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNT 588

  Fly   631 ASSLHLGVGGRPSSVSTLTIAS--VPPTLSGSGSPGGSVSGATTPLAPSLKALTPGPSNSSGHH- 692
            :..|      .|..::.:.:.|  |...|..:..|........|||:........|  ||||:. 
  Fly   589 SDPL------SPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFG--NSSGNSE 645

  Fly   693 ----VSFMPMTGMKRLRSSNASLGSPNGIISTVAGADTTSAPSLIDASEDQVQMR---------- 743
                ...|..:.::.:..|:|.|.|        ..|::|::|:      |.||.:          
  Fly   646 LALTYDLMTNSELRYMDESSAMLAS--------VTANSTTSPN------DSVQGKPPVLPPPPPA 696

  Fly   744 -------NQHRILEQCQSVQSQITTLGDVEDDDEEVSDSESESVGLALVVTTPQLESQPVE 797
                   |.::.|.|..| |:|                |.|:|:.|.|.....|.:||.:|
  Fly   697 RRNPPKSNLNQSLSQTPS-QNQ----------------SPSQSLSLNLNPNHNQSQSQSIE 740

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R2NP_001263072.1 7tmA_Dop1R2-like 122..485 CDD:320195 88/376 (23%)
TM helix 2 143..169 CDD:320195 14/25 (56%)
TM helix 3 182..212 CDD:320195 10/29 (34%)
TM helix 4 224..246 CDD:320195 4/21 (19%)
TM helix 5 266..295 CDD:320195 9/31 (29%)
TM helix 6 297..442 CDD:320195 19/145 (13%)
TM helix 7 453..478 CDD:320195 6/31 (19%)
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 60/179 (34%)
TM helix 2 168..194 CDD:320429 15/26 (58%)
TM helix 3 206..236 CDD:320429 10/29 (34%)
TM helix 4 248..271 CDD:320429 5/22 (23%)
TM helix 5 293..322 CDD:320429 8/28 (29%)
7tm_GPCRs <932..1008 CDD:475119
TM helix 6 941..963 CDD:410628
TM helix 7 976..1001 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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