DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Octbeta3R

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	960	Identity:	217/960 - (22%)
Similarity:	320/960 - (33%)	Gaps:	341/960 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 TELVLNATTSATS------------------ATLSPAMVATGGGGTTTPEPDLSE-FLEALPNDR 108
            |.|.|.||:|..|                  :|:.|.:.|.|.......:.:|.| :|     |.
  Fly    77 TSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPNITANGSDIAVDNQAELEESWL-----DL 136

  Fly   109 VGLLAFLFLFS---FATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEV 170
            ..||...|:||   .|.|.||:|||::|.|.|.|...||||:.|||:||.||.|..|.|:|..|:
  Fly   137 SLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVEL 201

  Fly   171 LENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWI 235
            ....|.||...|:::.||||.|||||||:||.||:|||:||..|..||:.||.|....::|.|||
  Fly   202 SGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWI 266

  Fly   236 CSSAISF-PAIVWWRAA----RDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRA 295
            ..:.||| |..:.|...    |:..:...:|:|..:..|.:.||::||::|.:||:..|.||::.
  Fly   267 LPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKE 331

  Fly   296 AVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSH--- 357
            |:.|.::|...:..:|:.|        :|.|.|.:..                   |||:.|
  Fly   332 AIRQRKALSRTSSNILLNS--------VHMGHTQQPT-------------------SLSYLHPSD 369

  Fly   358 ----------------------------------------------------------------- 357

  Fly   370 CDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYE 434

  Fly   358 --SH---------------SHHH--------------------------HHNHGGG-------TT 372
              :|               ||:.                          .|:|..|       |:
  Fly   435 KVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTS 499

  Fly   373 TSTPEEPDDEPLSALHNNGLARHRHMGKN-FSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFF 436
            .|...||:.|..:.....||......|.: :.....||:..||.|
  Fly   500 GSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELK-------------------- 544

  Fly   437 VVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSR-DFRRAFVRLLCMCCPRK-IRR 499
                      ..||...:.....|. |.|.|......||..|. ||.|  ::.....|.|| ...
  Fly   545 ----------RLIEDNYLYFKRQTG-GTIISGPGGGKYAALSETDFIR--LKAGAAACGRKAFAS 596

  Fly   500 KYQPTMRSKSQCHVAAAMVAASTSFGYHSVNQIDRTLMXRQLSSCSTC--------SGGSN---- 552
            .....:|:.|:..............|::.::.:.:|   |..:.|.|.        |.||:
  Fly   597 SDSEFLRTISESRALPEQPVPGKEKGFNILSLLSKT--KRSSTECFTLEKKRHQANSEGSSFFRR 659

  Fly   553 ------------CGGSR----SAHHQHHSSGTATPS-----------SSQRSCTRCQSFHRHHHR 590
                        |||.:    ....:.||...:||:           |.|...:..|.|
  Fly   660 SRNRKLSHSYNGCGGGKERKLERRQRQHSDTDSTPNKPDILLDINVLSEQSGASVIQQF------ 718

  Fly   591 SRRRSSGMQMRGDYNSTTAVNSALAKTIVTISAPPVAAASASSL-HLG--VGGRPSSVSTLTIAS 652
                |.|:|:. |::.              :..||....|...| .|.  .|..|...:|...:.
  Fly   719 ----SDGVQLI-DFSE--------------LKTPPERIRSDDELAQLADCFGESPQQPATPPPSL 764

  Fly   653 VPPTLSGSGSPGGSVSGATTPLAPSLKALT-------------------------PGPSNSSGHH 692
            .||.|.   .|.|.:..:::.||...::|:                         ..|.|:....
  Fly   765 SPPELP---EPSGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCANYLMSPPNTPAPP 826

  Fly   693 VSFMPMTG-MKRLRSSNASLGSPN-----------------GIISTVAGADTTSAPSLIDASEDQ 739
            ...:|..| |....||||...|.|                 ...|||:....||.|..:...:..
  Fly   827 AISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTSLPMPVPVPQPN 891

  Fly   740 VQMRNQHRILEQCQSVQSQITTLGDVEDDDEEVSDSESESVGLALVVTTP 789
            .||.:|..|..:.:.:..  :||..||...:|..|           ||:|
  Fly   892 PQMASQSNISPKPEIILD--STLSPVEGCGDEHRD-----------VTSP 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	79/176 (45%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	115/472 (24%)
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	85/199 (43%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	81/187 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460622
Domainoid	1	1.000	230	1.000	Domainoid score	I2451
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940