Protein Alignment Dop1R2 and mAChR-A

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Alignment Length: 779
• Identity: 169/779 - (21%)
• Similarity: 239/779 - (30%)
• Gaps: 358/779 - (45%)

  Fly    56 FNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEAL---------------- 104
            |..:.|||......|||.|:.|.|||..:.|..|||.    |:...|.|
  Fly    22 FKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTL----LTALFENLTSTAASGLYDPYSGMY 82

  Fly   105 ---PNDRVGL--------LAFLFLFSF-------ATVFGNSLVILAVIRERYLHTATNYFITSLA 151
               .|..:|.        ||.:.:..|       .||.||.:|:::...::.|.|.:|||:.|||
  Fly    83 GNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLA 147

  Fly   152 VADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFS 216
            :||..:|.:.||..|:..:| ..|..|...||.|.:||.|.|.||:|||.:||.|||:::|.|.:
  Fly   148 IADFAIGAISMPLFAVTTIL-GYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLT 211

  Fly   217 YPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGE--MPAYKC--TFTEHLGYLVFSSTI- 276
            |..:.|..|||.:|.|.|..|..:..|.|..|... :|:  :|..:|  .|.|...|:.|.:.:
  Fly   212 YRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYI-EGKRTVPKDECYIQFIETNQYITFGTALA 275

  Fly   277 SFYLPLLVMVFTYCRIYRAAVIQTR---SLKIGTKQ-------------VLMASGELQLTLRI-- 323
            :||.|:.:|.|.|.||:|....:.:   :|:.|.|.             |..|||.|....::
  Fly   276 AFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGG 340

  Fly   324 ----------------------------------------------------------------- 323
                                                                             
  Fly   341 NDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWW 405

  Fly   324 ----------------------------------------------------------------- 323
                                                                             
  Fly   406 HSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILL 470

  Fly   324 --------------------------------------------------HRG------------ 326
                                                              |.|
  Fly   471 SDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNG 535

  Fly   327 -----GTT-----RDQQ--------------------------------NQVSGGGGGGGGGGGG 349
                 |||     ||.:                                |..:|||||.|.|...
  Fly   536 SGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAA 600

  Fly   350 GGSLSHSHSHSHHHHHNHGGGTTTSTPEEP--------------DDE---PLS-----ALHN--- 389
            ..|||.....:......|..|.||:....|              |.|   ||.     |.|:
  Fly   601 SASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARL 665

  Fly   390 -NGLARHRHMGK-----------------NFSLSRKLAKFAKEK----KAAKTLGIVMGVFIICW 432
             |.....:.:||                 |...:.|..|.::||    ||||||..::..|||.|
  Fly   666 LNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITW 730

  Fly   433 LPFFVVNLLSGF--CIECIEHEEIVSAIVTW-----LGWINSCMNPVIYACWSRDFRRAFVRLL 489
            .|:.::.|:...  |.:||..|       .|     |.:|||.:||:.||..:..|||.:||:|
  Fly   731 TPYNILVLIKPLTTCSDCIPTE-------LWDFFYALCYINSTINPMCYALCNATFRRTYVRIL 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	142/673 (21%)
		TM helix 2	143..169	CDD:320195	12/25 (48%)
		TM helix 3	182..212	CDD:320195	17/29 (59%)
		TM helix 4	224..246	CDD:320195	8/21 (38%)
		TM helix 5	266..295	CDD:320195	10/29 (34%)
		TM helix 6	297..442	CDD:320195	57/443 (13%)
		TM helix 7	453..478	CDD:320195	9/29 (31%)
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	70/196 (36%)
		TM helix 1	106..132	CDD:320428	6/25 (24%)
		TM helix 2	139..165	CDD:320428	12/25 (48%)
		TM helix 3	177..207	CDD:320428	17/29 (59%)
		TM helix 4	219..242	CDD:320428	9/22 (41%)
		TM helix 5	265..294	CDD:320428	10/28 (36%)
		7tm_GPCRs	<707..783	CDD:475119	30/82 (37%)
		TM helix 6	716..738	CDD:410628	9/21 (43%)
		TM helix 7	751..776	CDD:410628	10/31 (32%)