Protein Alignment Dop1R2 and drd2b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_922918.1
• Gene: drd2b / 378719
• ZFINID: ZDB-GENE-030910-2
• Length: 452
• Species: Danio rerio
• Alignment Length: 441
• Identity: 151/441 - (34%)
• Similarity: 215/441 - (48%)
• Gaps: 95/441 - (21%)

  Fly   115 LFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGT 179
            |.|..|..||||.||.:||.||:.|.|.|||.|.||||||.||..:|||:....||: ..|.|..
Zfish    39 LTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV-GEWRFSK 102

  Fly   180 DWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVK-RAAGLIAAVWICSSAISFP 243
            ..|||:.:|||:..||||||||.||:|||.|:..|..|..|.:.| |...:|:.||:.|.|||.|
Zfish   103 IHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISCP 167

  Fly   244 AIVWWR--AARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIG 306
            .:....  |.|||.:    |... :..::|:||.:|||:|.::.:..|.:||  .|::.|..::.
Zfish   168 LLFGLNNTATRDGSV----CEIA-NPAFVVYSSIMSFYVPFIITLLVYVQIY--VVLRKRRKRVN 225

  Fly   307 TKQ----------------------------VLMASG-------ELQLTLRI-HRGG-------- 327
            ||:                            ::..:|       :.||...: |:||
Zfish   226 TKRSCQKTDADAQPPLKEKCTHPEDVKLCTVIIKTNGGVPAKNKKAQLIKEVLHQGGDVGMEMVA 290

  Fly   328 -------------------TTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTT 373
                               .|....|.               ||.||:...|:....| |.....
Zfish   291 GTSPPEKKKLASSLVVDLLATPPSPNH---------------GSPSHAEYQSNGDEKN-GHAKDV 339

  Fly   374 STPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVV 438
            .:|:|.......|| .||..| ..:.|..| .||:::. |||||.:.|.||:|||||||||||:.
Zfish   340 QSPKETKPVETQAL-PNGKTR-TTVTKTMS-KRKMSQH-KEKKATQMLAIVLGVFIICWLPFFIT 400

  Fly   439 NLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            ::|...|..|:...|:.:|. ||||::||.:||:||..::.:||:||:::|
Zfish   401 HILKTHCTSCVVPLEMYNAF-TWLGYVNSAVNPIIYTTFNVEFRKAFIKIL 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	145/428 (34%)
		TM helix 2	143..169	CDD:320195	15/25 (60%)
		TM helix 3	182..212	CDD:320195	20/29 (69%)
		TM helix 4	224..246	CDD:320195	10/22 (45%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	49/207 (24%)
		TM helix 7	453..478	CDD:320195	12/24 (50%)
drd2b	NP_922918.1	7tm_GPCRs	33..446	CDD:475119	148/435 (34%)
		TM helix 1	35..59	CDD:410628	11/19 (58%)
		TM helix 2	68..90	CDD:410628	14/21 (67%)
		TM helix 3	106..128	CDD:410628	14/21 (67%)
		TM helix 4	152..168	CDD:410628	7/15 (47%)
		TM helix 5	188..211	CDD:410628	7/22 (32%)
		TM helix 6	380..402	CDD:410628	14/21 (67%)
		TM helix 7	414..439	CDD:410628	12/25 (48%)