Protein Alignment Dop1R2 and HTR7

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_062873.1
• Gene: HTR7 / 3363
• HGNCID: 5302
• Length: 479
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 38/197 - (19%)
• Similarity: 68/197 - (34%)
• Gaps: 42/197 - (21%)

  Fly    52 AERHITTTTTTSLTTAPGTVGAVPVYEADEDGMIDITPGNGGLTNPNYSYSSYSANGGRQDGV-- 114
            |.:|.:...::.....||.....||            ||:..   ||...:..:.|...:...
Human   148 ANKHASQVLSSPCPNQPGDHAMPPV------------PGSSA---PNSPMAMLTLNSNCEKEAFY 197

  Fly   115 -GAPSSAANSSAPNITTTAGAS---------------SNGGASIGGGEGPGGMSSPTHTRFGRDF 163
             ....|.|.|..|.:.|.:.||               |:....|.|...|....:.|....|...
Human   198 KFEEQSRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLI 262

  Fly   164 HHSDHEGISFAGMTDTSD---DIPGIGQYEDFHTIDWQRDIARDRMR---HRYIVKKRQDSFWDL 222
            ....::|:...|:|.::.   ::|.|.:.   .|....|.:|::|.:   |..|.::|:.:..|.
Human   263 DLYSNQGLPPPGLTISNSCPANLPNIKRE---LTESEARALAKERQKKDNHNLIERRRRFNINDR 324

  Fly   223 LK 224
            :|
Human   325 IK 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	25/124 (20%)
		TM helix 2	143..169	CDD:320195	4/25 (16%)
		TM helix 3	182..212	CDD:320195	7/32 (22%)
		TM helix 4	224..246	CDD:320195	1/1 (100%)
		TM helix 5	266..295	CDD:320195
		TM helix 6	297..442	CDD:320195
		TM helix 7	453..478	CDD:320195
HTR7	NP_062873.1	7tmA_5-HT7	97..395	CDD:320452	38/197 (19%)
		TM helix 2	116..142	CDD:320452
		TM helix 3	155..185	CDD:320452	8/44 (18%)
		TM helix 4	197..219	CDD:320452	5/21 (24%)
		TM helix 5	236..265	CDD:320452	5/28 (18%)
		TM helix 6	320..350	CDD:320452	2/7 (29%)
		TM helix 7	363..388	CDD:320452