Protein Alignment Dop1R2 and HTR5A

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_076917.1
• Gene: HTR5A / 3361
• HGNCID: 5300
• Length: 357
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 125/426 - (29%)
• Similarity: 191/426 - (44%)
• Gaps: 82/426 - (19%)

  Fly    64 ELVLNATTSATSATLSPAMV--ATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGN 126
            :|.:|.|:.:.| |.||...  :.|........|.||.|...:    :.||.||...:||   .|
Human     2 DLPVNLTSFSLS-TPSPLETNHSLGKDDLRPSSPLLSVFGVLI----LTLLGFLVAATFA---WN 58

  Fly   127 SLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVL 191
            .||:..::|.|..|...:..:.|:||:|.||..:|||.|.::|:....|..|...|.:|.:.|||
Human    59 LLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVL 123

  Fly   192 FSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIV--WWRAARDG 254
            ..||||.|:..|:|||||:||....|.:|.....:..:||..|..|:.||...::  |.....:|
Human   124 CCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEG 188

  Fly   255 EMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQL 319
               :.:|..:....|.|||:..:|||||.|::|.|.:||:||     ..::|:::.
Human   189 ---SEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAA-----KFRVGSRKT--------- 236

  Fly   320 TLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPL 384
                          |.||                                  ..|...|..|
Human   237 --------------NSVS----------------------------------PISEAVEVKD--- 250

  Fly   385 SALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECI 449
            ||.....:...||....|.......:..||::||..:||::|||::||:|||:..|:|..| .|
Human   251 SAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC-SC- 313

  Fly   450 EHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAF 485
            :...|..:|..|||:.||..||:||..:::::..||
Human   314 DIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	105/364 (29%)
		TM helix 2	143..169	CDD:320195	10/25 (40%)
		TM helix 3	182..212	CDD:320195	16/29 (55%)
		TM helix 4	224..246	CDD:320195	6/21 (29%)
		TM helix 5	266..295	CDD:320195	14/28 (50%)
		TM helix 6	297..442	CDD:320195	27/144 (19%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
HTR5A	NP_076917.1	7tmA_5-HT5	41..349	CDD:320451	111/384 (29%)
		TM helix 1	42..68	CDD:320451	9/32 (28%)
		TM helix 2	75..101	CDD:320451	10/25 (40%)
		TM helix 3	114..144	CDD:320451	16/29 (55%)
		TM helix 4	156..177	CDD:320451	6/20 (30%)
		TM helix 5	197..226	CDD:320451	14/28 (50%)
		TM helix 6	278..308	CDD:320451	15/29 (52%)
		TM helix 7	317..342	CDD:320451	11/24 (46%)