Protein Alignment Dop1R2 and HTR4

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001035263.1
• Gene: HTR4 / 3360
• HGNCID: 5299
• Length: 428
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 152/512 - (29%)
• Similarity: 218/512 - (42%)
• Gaps: 140/512 - (27%)

  Fly   107 DRVGLLAFLFLFSFATVFGNSLVILAVIRERYLH-TATNYFITSLAVADCLVGLVVMPFSALYEV 170
            ::|.||.||.......:.||.||::||..:|.|. ..|||||.|||.||.||.::||||.|: |:
Human    18 EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAI-EL 81

  Fly   171 LENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAI-TDPFSYPMRMTVKRAAGLIAAVW 234
            :::.|.:|..:|.:..|||||.:||||.:||.||||||:|| ..|..|..:||..|.|.::...|
Human    82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCW 146

  Fly   235 ICSSAISF-PAIVWW-----------RAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVF 287
            :..:.||| |.:..|           |.........| |.|..:..|.:..|.::||:|.|:||.
Human   147 VIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTY-CVFMVNKPYAITCSVVAFYIPFLLMVL 210

  Fly   288 TYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGS 352
            .|.|||..|       |....|:.|          :.|.|.:
Human   211 AYYRIYVTA-------KEHAHQIQM----------LQRAGAS----------------------- 235

  Fly   353 LSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKA 417
             |.|...|...|..|                                          :...|.||
Human   236 -SESRPQSADQHSTH------------------------------------------RMRTETKA 257

  Fly   418 AKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFR 482
            ||||.|:||.|.:||.||||.|::..| |:.....::.:|.: |||:|||.:||.:||..::.||
Human   258 AKTLCIIMGCFCLCWAPFFVTNIVDPF-IDYTVPGQVWTAFL-WLGYINSGLNPFLYAFLNKSFR 320

  Fly   483 RAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFGYHSVNQI------DRTLMXRQL 541
            |||:.:|| |...:.||   |::..::        |..||:....|.:.:      ||.::.|..
Human   321 RAFLIILC-CDDERYRR---PSILGQT--------VPCSTTTINGSTHVLRTDFLFDRDILARYW 373

  Fly   542 SS--------------CSTC-----SGGSNCGGSRSAHHQHHSSGTATPSSSQRSCT 579
            :.              |.|.     .....|||...:  |.|...|:...::|.|.|
Human   374 TKPARAGPFSGTLSIRCLTARKPVLGDAVECGGQWES--QCHPPATSPLVAAQPSDT 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	121/376 (32%)
		TM helix 2	143..169	CDD:320195	17/25 (68%)
		TM helix 3	182..212	CDD:320195	20/30 (67%)
		TM helix 4	224..246	CDD:320195	7/22 (32%)
		TM helix 5	266..295	CDD:320195	12/28 (43%)
		TM helix 6	297..442	CDD:320195	28/144 (19%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
HTR4	NP_001035263.1	7tmA_5-HT4	20..323	CDD:320184	126/389 (32%)
		TM helix 1	21..47	CDD:320184	10/25 (40%)
		TM helix 2	55..81	CDD:320184	17/26 (65%)
		TM helix 3	93..123	CDD:320184	19/29 (66%)
		TM helix 4	136..159	CDD:320184	7/22 (32%)
		TM helix 5	189..218	CDD:320184	12/28 (43%)
		TM helix 6	252..282	CDD:320184	18/29 (62%)
		TM helix 7	291..316	CDD:320184	11/25 (44%)