DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop1R2 and HTR2A

DIOPT Version :10

Sequence 1:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster
Sequence 2:NP_000612.1 Gene:HTR2A / 3356 HGNCID:5293 Length:471 Species:Homo sapiens


Alignment Length:491 Identity:138/491 - (28%)
Similarity:225/491 - (45%) Gaps:119/491 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 ISEDVYFY---FNGLPTSTELVLNATTSATSAT-------LSPAMVATGGGGTTTPEPDLSEFLE 102
            :::|...|   ||....:|....|.|..:.:.|       |||:.::.    ....|.:.|..|.
Human    21 LNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSL----LHLQEKNWSALLT 81

  Fly   103 ALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSAL 167
            |:    |.:|         |:.||.|||:||..|:.|..|||||:.|||:||.|:|.:|||.|.|
Human    82 AV----VIIL---------TIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSML 133

  Fly   168 YEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAA 232
            ..:....|...:..|.:|..||||||||||::||.||||||.||.:|..:....:..:|...|.|
Human   134 TILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIA 198

  Fly   233 VWICSSAISFPAIVWW-----RAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRI 292
            ||..|..||.|..|:.     :..::|     .|...:. .:::..|.:||::||.:||.||   
Human   199 VWTISVGISMPIPVFGLQDDSKVFKEG-----SCLLADD-NFVLIGSFVSFFIPLTIMVITY--- 254

  Fly   293 YRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSH 357
                .:..:||:   |:..:...:|                                 |:.:...
Human   255 ----FLTIKSLQ---KEATLCVSDL---------------------------------GTRAKLA 279

  Fly   358 SHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLAR---HRHMGKNFSLSRKLAKFAKEKKAAK 419
            |.|.                    .|.|:|.:..|.:   ||..| :::..|.:...:.|:||.|
Human   280 SFSF--------------------LPQSSLSSEKLFQRSIHREPG-SYTGRRTMQSISNEQKACK 323

  Fly   420 TLGIVMGVFIICWLPFFVVNLLSGFCIE-CIEHEEIVSAIV---TWLGWINSCMNPVIYACWSRD 480
            .||||..:|::.|.|||:.|:::..|.| |  :|:::.|::   .|:|:::|.:||::|..:::.
Human   324 VLGIVFFLFVVMWCPFFITNIMAVICKESC--NEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKT 386

  Fly   481 FRRAFVRLLCMCCPRKIRRKYQ-------PTMRSKS 509
            :|.||.|.: .|..::.::..|       |.:..||
Human   387 YRSAFSRYI-QCQYKENKKPLQLILVNTIPALAYKS 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R2NP_001263072.1 7tmA_Dop1R2-like 122..485 CDD:320195 113/374 (30%)
TM helix 2 143..169 CDD:320195 16/25 (64%)
TM helix 3 182..212 CDD:320195 21/29 (72%)
TM helix 4 224..246 CDD:320195 9/21 (43%)
TM helix 5 266..295 CDD:320195 9/28 (32%)
TM helix 6 297..442 CDD:320195 29/147 (20%)
TM helix 7 453..478 CDD:320195 7/27 (26%)
HTR2ANP_000612.1 7tmA_5-HT2A 75..391 CDD:341345 118/400 (30%)
TM helix 1 76..102 CDD:341345 13/38 (34%)
TM helix 2 109..135 CDD:341345 16/25 (64%)
TM helix 3 148..178 CDD:341345 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 9/22 (41%)
TM helix 5 231..260 CDD:341345 9/36 (25%)
TM helix 6 316..346 CDD:341345 14/29 (48%)
TM helix 7 359..384 CDD:341345 7/24 (29%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..471
PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405 469..471
Blue background indicates that the domain is not in the aligned region.

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