Protein Alignment Dop1R2 and HTR1E

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_000856.1
• Gene: HTR1E / 3354
• HGNCID: 5291
• Length: 365
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 136/437 - (31%)
• Similarity: 209/437 - (47%)
• Gaps: 93/437 - (21%)

  Fly    66 VLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVI 130
            :.|.||.|:.| :.|..:                      .:::.:...|.:.:..|...|..||
Human     3 ITNCTTEASMA-IRPKTI----------------------TEKMLICMTLVVITTLTTLLNLAVI 44

  Fly   131 LAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTA 195
            :|:...:.||...||.|.||||.|.||.::|||.|.:|.|::. |..|...|::|.|:|:...|.
Human    45 MAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDR-WKLGYFLCEVWLSVDMTCCTC 108

  Fly   196 SILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYK 260
            |||:||||:||||||||:...|..:.|.||||.:|..||..|..||.|.: :||:.|....|..:
Human   109 SILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPL-FWRSHRRLSPPPSQ 172

  Fly   261 CTFT-EHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSL--KIGTKQVLMASGELQLTLR 322
            ||.. :|:.|.::|:..:||:||.:::..|.|||.||    :||  |.|:.:
Human   173 CTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAA----KSLYQKRGSSR------------- 220

  Fly   323 IHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPE---------- 377
             |....:.|.||..:            ...|:.:...|..       .|:..|.|
Human   221 -HLSNRSTDSQNSFA------------SCKLTQTFCVSDF-------STSDPTTEFEKFHASIRI 265

  Fly   378 EPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLS 442
            .|.|..|.           |.|:...:|.     .:|:|||:.||:::|.||:.|||||:..|:.
Human   266 PPFDNDLD-----------HPGERQQISS-----TRERKAARILGLILGAFILSWLPFFIKELIV 314

  Fly   443 GFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            |..|..:..|  |:..:||||::||.:||::|..::.||:.||.:|:
Human   315 GLSIYTVSSE--VADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLI 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	126/375 (34%)
		TM helix 2	143..169	CDD:320195	14/25 (56%)
		TM helix 3	182..212	CDD:320195	18/29 (62%)
		TM helix 4	224..246	CDD:320195	11/21 (52%)
		TM helix 5	266..295	CDD:320195	11/28 (39%)
		TM helix 6	297..442	CDD:320195	34/156 (22%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
HTR1E	NP_000856.1	7tmA_5-HT1E	23..355	CDD:320457	127/388 (33%)
		TM helix 1	24..50	CDD:320457	6/25 (24%)
		TM helix 2	57..83	CDD:320457	14/25 (56%)
		TM helix 3	95..125	CDD:320457	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	119..121		1/1 (100%)
		TM helix 4	137..159	CDD:320457	11/22 (50%)
		TM helix 5	179..208	CDD:320457	11/28 (39%)
		TM helix 6	284..314	CDD:320457	15/29 (52%)
		TM helix 7	323..348	CDD:320457	11/26 (42%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	340..344		2/3 (67%)