DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dop1R2 and HTR1B

DIOPT Version :9

Sequence 1:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster
Sequence 2:NP_000854.1 Gene:HTR1B / 3351 HGNCID:5287 Length:390 Species:Homo sapiens


Alignment Length:425 Identity:146/425 - (34%)
Similarity:209/425 - (49%) Gaps:69/425 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 GGGTTTPEPDLSEFLEALPND-----------------RVGLLAFLFLFSFATVFGNSLVILAVI 134
            |..|..|:.:||    :.|:.                 :|.|:..|.|.:.||...|:.||..|.
Human    15 GSETWVPQANLS----SAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVY 75

  Fly   135 RERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILN 199
            |.|.|||..||.|.||||.|.||.::|||.|.:|.| ...|..|...||.|.|.|:...|||||:
Human    76 RTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASILH 139

  Fly   200 LCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTF- 263
            ||||:|||||||||...|..:.|.||||.:||.||:.|.:||.|...|.:|..:.|:.  :|.. 
Human   140 LCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVS--ECVVN 202

  Fly   264 TEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGT 328
            |:|:.|.|:|:..:||.|.|:::..|.|||    ::.||..:  ||....:|:     |:.|...
Human   203 TDHILYTVYSTVGAFYFPTLLLIALYGRIY----VEARSRIL--KQTPNRTGK-----RLTRAQL 256

  Fly   329 TRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLA 393
            ..|..              |...|::..:|.               .|:.|.:.......|....
Human   257 ITDSP--------------GSTSSVTSINSR---------------VPDVPSESGSPVYVNQVKV 292

  Fly   394 RHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAI 458
            |    ..:..|.:|....|:|:||.|||||::|.||:||||||:::|:...|.:.......:...
Human   293 R----VSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDF 353

  Fly   459 VTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCC 493
            .||||::||.:||:||...:.||::||.:|:...|
Human   354 FTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R2NP_001263072.1 7tm_4 123..>295 CDD:304433 81/172 (47%)
7tm_1 125..474 CDD:278431 126/349 (36%)
HTR1BNP_000854.1 7tmA_5-HT1B_1D 46..380 CDD:320455 136/380 (36%)
TM helix 1 51..77 CDD:320455 9/25 (36%)
TM helix 2 84..110 CDD:320455 14/25 (56%)
TM helix 3 122..152 CDD:320455 20/29 (69%)
Agonist binding 125..134 3/8 (38%)
DRY motif, important for ligand-induced conformation changes and signaling 146..148 1/1 (100%)
TM helix 4 164..187 CDD:320455 12/22 (55%)
TM helix 5 205..234 CDD:320455 12/32 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..281 6/50 (12%)
TM helix 6 307..337 CDD:320455 19/29 (66%)
Agonist binding 327..331 3/3 (100%)
TM helix 7 348..373 CDD:320455 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling 365..369 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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