DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Dop2R

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster

Alignment Length:	663	Identity:	181/663 - (27%)
Similarity:	256/663 - (38%)	Gaps:	228/663 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VEGAEGAGAPLLALLRVDGLNQTQTRSPSPSFFGSYNISEDVYFYFNGLPTSTELVLNATTSATS 75
            |.||.|:|.....|| ::..|         .:|.:||                    .:|.|.||
  Fly   288 VGGAGGSGGSTFMLL-LENFN---------DYFPNYN--------------------GSTVSGTS 322

  Fly    76 ATLSPAMVATG--GGGTTTPEPDLSEFLEA----LPNDRVGL---------------LAFLFLFS 119
             |::|.:..||  |.|....:.....:|:.    ..|:.:.|               ...|.||.
  Fly   323 -TIAPGVAITGSRGSGLLLEQNLTGLYLDGYRLNCTNETLNLTDSCGELRVVDHNYWALILILFP 386

  Fly   120 FATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDI 184
            ..|:|||.||||:|.|||.|.|.|||||.|||:||.||.:||||| |:|.::...|......||.
  Fly   387 ILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPF-AVYFLVNGAWALPDVVCDF 450

  Fly   185 WRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWR 249
            :.::||:.||:||.||..||:|||.|:|.|..|......:|....|..||..|:||..|.::...
  Fly   451 YIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPIVLGLN 515

  Fly   250 AARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAA------------------ 296
            ...:.|...  |.| .:..::::||..|||:|.::|||.|..|::|.
  Fly   516 NTPNREPDV--CAF-YNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRAARKPHLSEL 577

  Fly   297 --------VIQTRSL-------KIGTKQVL-------MASG------------------------ 315
                    :.|||.|       .....::|       .|||
  Fly   578 TGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDIDDCHVIVNDK 642

  Fly   316 --ELQLTLRIHRGG-------TTRDQQNQVSGGGGGGGG----------GGGGGGSLSHSHSHSH 361
              |..|...:...|       ||:.|.......|....|          .|....|.|.:.|.:.
  Fly   643 STEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAP 707

  Fly   362 HHHHNHGGGTTTSTPEEP--------------------DDEPL---SALHNNG------------ 391
            .        ::.|.|:.|                    ||.|.   .||.:.|
  Fly   708 R--------SSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAMKPLS 764

  Fly   392 -----------LARH------------RHMGKNFSLSR----KLAKFA----------KEKKAAK 419
                       |||:            |...||...||    |:.|.:          ||:||.|
  Fly   765 FVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKERKATK 829

  Fly   420 TLGIVMGVFIICWLPFFVVNLLSGFCI----ECIEHEEIVSA--IVTWLGWINSCMNPVIYACWS 478
            ||.||:|||:.||||||..|::...|.    :|   ...::|  :.||||:|||.:|||||..::
  Fly   830 TLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDC---RPGLTAYMMTTWLGYINSFVNPVIYTIFN 891

  Fly   479 RDFRRAFVRLLCM 491
            .:||:||.:::.|
  Fly   892 PEFRKAFKKIMHM 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	74/171 (43%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	145/509 (28%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	79/192 (41%)
		TM helix 1	377..403	CDD:320181	12/25 (48%)
		TM helix 2	410..436	CDD:320181	19/26 (73%)
		TM helix 3	448..478	CDD:320181	16/29 (55%)
		TM helix 4	490..513	CDD:320181	8/22 (36%)
		TM helix 5	529..558	CDD:320181	11/28 (39%)
		7tm_GPCRs	<822..898	CDD:333717	36/78 (46%)
		TM helix 6	825..850	CDD:320095	16/24 (67%)
		TM helix 7	866..891	CDD:320095	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460615
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940