DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Adra1a

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_058887.2	Gene:	Adra1a / 29412	RGDID:	2055	Length:	466	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	162/491 - (32%)
Similarity:	242/491 - (49%)	Gaps:	113/491 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTW 175
            :|..|.:|.   |.||.||||:|...|:||:.|:|:|.:|||||.|:...|:||||::|:| ..|
  Rat    32 ILGGLIIFG---VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL-GYW 92

  Fly   176 FFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAI 240
            .||..:|:||.::|||..||||:.||:||:|||..::.|..||..:|.:|....:..||:.|..|
  Rat    93 AFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVI 157

  Fly   241 SFPAIVWWR--AARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSL 303
            |...:..||  |..|..:    |...|..||::||:..|||:||.:::..|||:|..|..::|.|
  Rat   158 SIGPLFGWRQPAPEDETI----CQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGL 218

  Fly   304 KIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHG 368
            |.|.|  ...|...|:||||||.....:                |||.|.:.:.:|
  Rat   219 KSGLK--TDKSDSEQVTLRIHRKNVPAE----------------GGGVSSAKNKTH--------- 256

  Fly   369 GGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWL 433
                                             ||:  :|.||::|||||||||||:|.|::|||
  Rat   257 ---------------------------------FSV--RLLKFSREKKAAKTLGIVVGCFVLCWL 286

  Fly   434 PFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIR 498
            |||:|..:..|..: .:..|.|..||.|||::|||:||:||.|.|::|::||..:|.:.|   :|
  Rat   287 PFFLVMPIGSFFPD-FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC---LR 347

  Fly   499 RKYQP------TMRSKSQC----HVAAAMVAASTSFGYHSVNQID----------------RTLM 537
            |:...      |:...||.    |.....:...:...::.:::.|                |..:
  Rat   348 RRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITV 412

  Fly   538 XRQLSSCSTCSGGSN-------CGGSRS----AHHQ 562
            .:..|:|:|....|.       |.||.:    .:||
  Rat   413 PKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQ 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	76/173 (44%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	132/350 (38%)
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	141/375 (38%)
		TM helix 1	29..53	CDD:320448	11/23 (48%)
		TM helix 2	62..84	CDD:320448	11/21 (52%)
		TM helix 3	100..122	CDD:320448	12/21 (57%)
		TM helix 4	145..161	CDD:320448	5/15 (33%)
		TM helix 5	182..205	CDD:320448	9/22 (41%)
		TM helix 6	271..293	CDD:320448	16/21 (76%)
		TM helix 7	305..330	CDD:320448	15/24 (63%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BB8F
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001183
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X580
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810