Protein Alignment Dop1R2 and Drd3

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_058836.1
• Gene: Drd3 / 29238
• RGDID: 2521
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 433
• Identity: 142/433 - (32%)
• Similarity: 204/433 - (47%)
• Gaps: 94/433 - (21%)

  Fly   121 ATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIW 185
            |.:|||.||..||:|||.|.|.|||.:.||||||.||..:|||:....||....|.|....||::
  Rat    42 AIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVF 106

  Fly   186 RSLDVLFSTASILNLCVISLDRYWAITDPFSYPM---RMTVKRAAGLIAAVWICSSAISFPAIVW 247
            .:|||:..||||||||.||:|||.|:..|..|..   :.:.:|.|.:|.|||:.:.|:|.|.:..
  Rat   107 VTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFG 171

  Fly   248 WRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLK-IGTKQ-- 309
            :....|..:    |:.: :..::::||.:|||:|..|.|..|.|||  .|::.|..| |.|:|
  Rat   172 FNTTGDPSI----CSIS-NPDFVIYSSVVSFYVPFGVTVLVYARIY--IVLRQRQRKRILTRQNS 229

  Fly   310 --VLMASGELQLT--LRIH-------RGGTTRDQQNQVSGGGGGGGGGGGGGGSLSH-------- 355
              :.:..|..|.:  ||:|       |.....|                 ..|.:.|
  Rat   230 QCISIRPGFPQQSSCLRLHPIRQFSIRARFLSD-----------------ATGQMEHIEDKQYPQ 277

  Fly   356 -------SHSHSHHHHHNHGG-------------------GTTTSTPEE-------PDDEPLSAL 387
                   ||.........|||                   |....:|.|       |...|..:|
  Rat   278 KCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSL 342

  Fly   388 HNNGLARHRHMGKNFSLSRKLAKF------AKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCI 446
            ....|:..|     .|.|.:|...      .:||||.:.:.||:|.||:||||||:.::|:..|.
  Rat   343 EVRKLSNGR-----LSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQ 402

  Fly   447 ECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            .|....|:..| .||||::||.:|||||..::.:||:||:::|
  Rat   403 ACHVSPELYRA-TTWLGYVNSALNPVIYTTFNVEFRKAFLKIL 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	138/426 (32%)
		TM helix 2	143..169	CDD:320195	14/25 (56%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	9/21 (43%)
		TM helix 5	266..295	CDD:320195	12/28 (43%)
		TM helix 6	297..442	CDD:320195	46/205 (22%)
		TM helix 7	453..478	CDD:320195	13/24 (54%)
Drd3	NP_058836.1	7tmA_D3_dopamine_R	30..440	CDD:320436	139/427 (33%)
		TM helix 1	31..57	CDD:320436	8/14 (57%)
		TM helix 2	64..87	CDD:320436	14/22 (64%)
		TM helix 3	103..133	CDD:320436	19/29 (66%)
		TM helix 4	150..168	CDD:320436	7/17 (41%)
		TM helix 5	185..210	CDD:320436	9/24 (38%)
		TM helix 6	368..398	CDD:320436	15/29 (52%)
		TM helix 7	408..433	CDD:320436	13/25 (52%)