Protein Alignment Dop1R2 and adra2db

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_919346.1
• Gene: adra2db / 266755
• ZFINID: ZDB-GENE-021010-5
• Length: 415
• Species: Danio rerio
• Alignment Length: 455
• Identity: 138/455 - (30%)
• Similarity: 211/455 - (46%)
• Gaps: 78/455 - (17%)

  Fly    59 LPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATV 123
            ||.|:|     .|:.|||...|            |....:..|         ::..:.:....|:
Zfish    10 LPNSSE-----DTNGTSAPRLP------------PHSQCASVL---------IVLVVTVIILVTI 48

  Fly   124 FGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSL 188
            .||.||::||...|.|....|.|:.|||.||.||..:|:|||...||: ..|:.|:.||..:.:|
Zfish    49 VGNVLVVVAVFTSRALRAPQNLFLVSLAAADILVATLVIPFSLANEVM-GYWYLGSTWCAFYLAL 112

  Fly   189 DVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARD 253
            ||||.|:||::||.|||||||::|...||.::.|.:|...:|..||:.|:.||||.::   ..:.
Zfish   113 DVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPRRIKIMITVVWVISAVISFPPLL---MTKH 174

  Fly   254 GEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQ 318
            .|:   :|.......|::.|..:||:.|.|:|:..||||||.|. |..|.....|..:.......
Zfish   175 DEL---ECLLNNETWYILSSCIVSFFAPGLIMILVYCRIYRVAK-QRASTVFVAKNGMERQPSQS 235

  Fly   319 LTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGG----------SLSHSHSHSHHHHHNHGGGTTT 373
            .|..:.:|      :::|........|.....|          |:|:.|.:|.........|..:
Zfish   236 ETCFVRKG------KSEVESPSSHSSGSRERKGELDDIDLEESSVSNRHRNSRFAKSRKVEGAQS 294

  Fly   374 ------------STPEEPDDEPLSALHNNGLARHRHMGKNFSLSR-KLAKFAKEKKAAKTLGIVM 425
                        |...|.:.||              ..:..|||: |||:. :||:....|.:||
Zfish   295 CPKPNGRLSWACSRASELEQEP--------------RARQLSLSKSKLAQM-REKRFTFVLAVVM 344

  Fly   426 GVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLC 490
            |||::||.|||....|...|.:.....:.:..:..|:|:.||.:||:||..::||||:||.:::|
Zfish   345 GVFVLCWFPFFFTYSLHAICRKSCTIPDSLFNLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKIMC 409

  Fly   491  490
            Zfish   410  409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	124/385 (32%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	18/29 (62%)
		TM helix 4	224..246	CDD:320195	9/21 (43%)
		TM helix 5	266..295	CDD:320195	12/28 (43%)
		TM helix 6	297..442	CDD:320195	36/167 (22%)
		TM helix 7	453..478	CDD:320195	8/24 (33%)
adra2db	NP_919346.1	7tmA_alpha-2D_AR	59..404	CDD:320447	117/373 (31%)
		TM helix 2	68..94	CDD:320447	13/25 (52%)
		TM helix 3	106..136	CDD:320447	18/29 (62%)
		TM helix 4	148..171	CDD:320447	9/25 (36%)
		TM helix 5	184..213	CDD:320447	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..299		10/70 (14%)
		TM helix 6	331..361	CDD:320447	13/30 (43%)
		TM helix 7	372..397	CDD:320447	8/24 (33%)