Protein Alignment Dop1R2 and adra2da

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_919345.2
• Gene: adra2da / 266754
• ZFINID: ZDB-GENE-021010-4
• Length: 408
• Species: Danio rerio
• Alignment Length: 458
• Identity: 137/458 - (29%)
• Similarity: 212/458 - (46%)
• Gaps: 91/458 - (19%)

  Fly    77 TLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHT 141
            :::||..:|......|..|.|..:.|  |...: ::..:.|....|:.||.|||:||:..|.|..
Zfish     2 SVTPAANSTEEAANITASPRLWPYTE--PASAI-IILVVSLIILLTIVGNVLVIVAVLTSRALRA 63

  Fly   142 ATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLD 206
            ..|.|:.|||.||.||..:|:|||...|:: ..|:||:.||..:.:|||||.|:||::||.||||
Zfish    64 PQNLFLVSLACADILVATLVIPFSLANEIM-GYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLD 127

  Fly   207 RYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFTEHLGYLV 271
            |||::|....|.::.|.:|...:||.||:.|:.||||.::..:  .|.:    :|...:...|::
Zfish   128 RYWSVTKAVRYNLKRTPRRIKCMIAVVWLISAVISFPPLIMTK--HDEK----ECLINDETWYIL 186

  Fly   272 FSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQL------TLRIHRGGTTR 330
            .|..:||:.|.|:|:..||:|||.|       |..:..|.:|...|:.      |..:.:....:
Zfish   187 SSCAVSFFAPGLIMITVYCKIYRVA-------KQRSSTVFVAKNGLERQPSQSETCFVRKDKFEK 244

  Fly   331 DQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARH 395
            :                    |.|.:.|.|            ....||.||   ..|..:..:..
Zfish   245 E--------------------SPSSNSSES------------AQRQEELDD---IDLEESAASDS 274

  Fly   396 RHMGKNFSLSRKL-------------------------------AKFA--KEKKAAKTLGIVMGV 427
            |..|..||..|::                               :|.|  :||:....|.:||||
Zfish   275 RARGSRFSKRRRVEGERRGPQRSCRVSWAAHQEPGSRQQQLASKSKVAQMREKRFTFVLAVVMGV 339

  Fly   428 FIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMC 492
            |::||.|||....|...|.|.....|.:..:..|:|:.||.:||:||..::||||:||.:::|..
Zfish   340 FVLCWFPFFFTYSLQAVCGERCGPPEALFKLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKVVCWS 404

  Fly   493 CPR 495
            ..|
Zfish   405 AQR 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	124/401 (31%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	18/29 (62%)
		TM helix 4	224..246	CDD:320195	10/21 (48%)
		TM helix 5	266..295	CDD:320195	11/28 (39%)
		TM helix 6	297..442	CDD:320195	34/183 (19%)
		TM helix 7	453..478	CDD:320195	9/24 (38%)
adra2da	NP_919345.2	7tmA_alpha-2D_AR	44..397	CDD:320447	124/401 (31%)
		TM helix 2	65..91	CDD:320447	13/25 (52%)
		TM helix 3	103..133	CDD:320447	18/29 (62%)
		TM helix 4	145..168	CDD:320447	10/22 (45%)
		TM helix 5	181..210	CDD:320447	11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..306		14/98 (14%)
		TM helix 6	324..354	CDD:320447	13/29 (45%)
		TM helix 7	365..390	CDD:320447	9/24 (38%)