Protein Alignment Dop1R2 and Htr5a

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_037280.1
• Gene: Htr5a / 25689
• RGDID: 2851
• Length: 357
• Species: Rattus norvegicus
• Alignment Length: 435
• Identity: 127/435 - (29%)
• Similarity: 190/435 - (43%)
• Gaps: 100/435 - (22%)

  Fly    64 ELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAF----LFLFSF---A 121
            :|.:|.|:.:.|.             .:|.||:.|...|||...:..|.||    |.|..|   |
  Rat     2 DLPINLTSFSLST-------------PSTLEPNRSLDTEALRTSQSFLSAFRVLVLTLLGFLAAA 53

  Fly   122 TVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWR 186
            |...|.||:..::|.|..|...:..:.|:|::|.||.::|||.|.::|:....|..|...|.:|.
  Rat    54 TFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWI 118

  Fly   187 SLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISF-PAIVWWRA 250
            :.|||..||||.|:..|:|||||:||....|.:|...:.:..:|...|..|:.||. |.:..|
  Rat   119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRARKRVSNVMILLTWALSAVISLAPLLFGW-- 181

  Fly   251 ARDGEMPAY-----KCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQV 310
               ||  .|     :|..:....|.|||:..:|||||.|::|.|.:||:||     ..::|:::.
  Rat   182 ---GE--TYSELSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAA-----KFRMGSRKT 236

  Fly   311 LMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTST 375
                                   |.||                                    ..
  Rat   237 -----------------------NSVS------------------------------------PI 242

  Fly   376 PEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNL 440
            ||..:.:..|. |...:...||....|.......:..||::||..:||::|||::||.||||..|
  Rat   243 PEAVEVKDASQ-HPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTEL 306

  Fly   441 LSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAF 485
            :|..|...|  ..:..:|..|||:.||..||:||..::|.:..||
  Rat   307 ISPLCSWDI--PALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	107/368 (29%)
		TM helix 2	143..169	CDD:320195	9/25 (36%)
		TM helix 3	182..212	CDD:320195	16/29 (55%)
		TM helix 4	224..246	CDD:320195	6/22 (27%)
		TM helix 5	266..295	CDD:320195	14/28 (50%)
		TM helix 6	297..442	CDD:320195	27/144 (19%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
Htr5a	NP_037280.1	7tm_GPCRs	41..349	CDD:475119	111/381 (29%)
		TM helix 1	43..67	CDD:320451	8/23 (35%)
		TM helix 2	76..98	CDD:320451	8/21 (38%)
		TM helix 3	115..137	CDD:320451	10/21 (48%)
		TM helix 4	160..176	CDD:320451	5/15 (33%)
		TM helix 5	198..221	CDD:320451	11/22 (50%)
		TM helix 6	284..306	CDD:320451	12/21 (57%)
		TM helix 7	317..342	CDD:320451	10/24 (42%)