Protein Alignment Dop1R2 and Adrb3

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_008769537.1
• Gene: Adrb3 / 25645
• RGDID: 2061
• Length: 421
• Species: Rattus norvegicus
• Alignment Length: 480
• Identity: 160/480 - (33%)
• Similarity: 210/480 - (43%)
• Gaps: 123/480 - (25%)

  Fly    26 RVDGLN-QTQTR---SPSPSFFGSYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATG 86
            ||.|.| .:|||   :|.|...||.....|                       :.||.|:...|.
  Rat     8 RVWGENFPSQTRHEMAPWPHKNGSLAFWSD-----------------------APTLDPSAANTS 49

  Fly    87 GGGTTTPEPDLSEFLEALPNDRVGLLAFL--FLFSFATVFGNSLVILAVIRERYLHTATNYFITS 149
            |                ||.  |...|.|  .|.:.|||.||.|||.|:.|...|.|.||.|:||
  Rat    50 G----------------LPG--VPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTS 96

  Fly   150 LAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDP 214
            ||.||.:|||:|||..|.. .|...|..|...|::|.|:|||..||||..||.:::|||.|:|:|
  Rat    97 LATADLVVGLLVMPPGATL-ALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNP 160

  Fly   215 FSYPMRMTVKRAAGLIAAVWICSSAISFPAIV--WWRAARDGEMPAYK-----CTFTEHLGYLVF 272
            ..|...:|.:||...:..|||.|:.:||..|:  |||...|.|.....     |:|..::.|.:.
  Rat   161 LRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALL 225

  Fly   273 SSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVS 337
            ||::|||||||||:|.|.|::..|..|.|                  .||...|....::..:
  Rat   226 SSSVSFYLPLLVMLFVYARVFVVAKRQRR------------------LLRRELGRFPPEESPR-- 270

  Fly   338 GGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNF 402
                            |.|.|.|         ..|..||...|..|
  Rat   271 ----------------SPSRSPS---------PATVGTPTASDGVP------------------- 291

  Fly   403 SLSRKLAKFAK--EKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWI 465
            |..|:.|:...  |.:|.:|||::||:|.:||||||:.|:|.......:....:..|: .|||:.
  Rat   292 SCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIAL-NWLGYA 355

  Fly   466 NSCMNPVIYACWSRDFRRAFVRLLC 490
            ||..||:|| |.|.|||.||.||||
  Rat   356 NSAFNPLIY-CRSPDFRDAFRRLLC 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	130/371 (35%)
		TM helix 2	143..169	CDD:320195	16/25 (64%)
		TM helix 3	182..212	CDD:320195	16/29 (55%)
		TM helix 4	224..246	CDD:320195	8/21 (38%)
		TM helix 5	266..295	CDD:320195	15/28 (54%)
		TM helix 6	297..442	CDD:320195	32/146 (22%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
Adrb3	XP_008769537.1	7tm_GPCRs	69..374	CDD:475119	130/371 (35%)
		TM helix 2	91..113	CDD:410628	14/21 (67%)
		TM helix 3	129..151	CDD:410628	11/21 (52%)
		TM helix 4	174..190	CDD:410628	6/15 (40%)
		TM helix 5	220..243	CDD:410628	13/22 (59%)
		TM helix 6	309..331	CDD:410628	12/21 (57%)
		TM helix 7	343..368	CDD:410628	11/26 (42%)