Protein Alignment Dop1R2 and Htr1b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_071561.1
• Gene: Htr1b / 25075
• RGDID: 2846
• Length: 386
• Species: Rattus norvegicus
• Alignment Length: 462
• Identity: 152/462 - (32%)
• Similarity: 215/462 - (46%)
• Gaps: 94/462 - (20%)

  Fly    33 TQTRSPSPSFFGSYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDL 97
            :||..|..:.  |:|.|.|.|.|.:.:
  Rat    16 SQTGVPLANL--SHNCSADDYIYQDSI-------------------------------------- 40

  Fly    98 SEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVM 162
                 ||| .:|.|:|.|.|.:.||...|:.||..|.|.|.|||..||.|.||||.|.||.::||
  Rat    41 -----ALP-WKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVM 99

  Fly   163 PFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAA 227
            |.|.:|.| ...|..|...||.|.|.|:...||||::||||:|||||||||...|..:.|.||||
  Rat   100 PISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAA 163

  Fly   228 GLIAAVWICSSAISFPAIVWWRAARDGEMPAYKC-TFTEHLGYLVFSSTISFYLPLLVMVFTYCR 291
            .:|..||:.|.:||.|...|.:|..:.|:  ..| ..|:|:.|.|:|:..:||||.|:::..|.|
  Rat   164 IMIVLVWVFSISISLPPFFWRQAKAEEEV--LDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGR 226

  Fly   292 IYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHS 356
            ||    ::.||..:  ||....:|:     |:.|.....|..              |...|::..
  Rat   227 IY----VEARSRIL--KQTPNKTGK-----RLTRAQLITDSP--------------GSTSSVTSI 266

  Fly   357 HSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTL 421
            :|.               .||.|.:.......|....|    ..:..|.:|....|:|:||.|||
  Rat   267 NSR---------------VPEVPSESGSPVYVNQVKVR----VSDALLEKKKLMAARERKATKTL 312

  Fly   422 GIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFV 486
            ||::|.||:||||||:::|:...|.:.......:.....|||::||.:||:||...:.||::||.
  Rat   313 GIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFH 377

  Fly   487 RLLCMCC 493
            :|:...|
  Rat   378 KLIRFKC 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	130/363 (36%)
		TM helix 2	143..169	CDD:320195	14/25 (56%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	11/21 (52%)
		TM helix 5	266..295	CDD:320195	13/28 (46%)
		TM helix 6	297..442	CDD:320195	37/144 (26%)
		TM helix 7	453..478	CDD:320195	9/24 (38%)
Htr1b	NP_071561.1	7tmA_5-HT1B_1D	42..376	CDD:320455	138/381 (36%)
		TM helix 1	47..73	CDD:320455	10/25 (40%)
		TM helix 2	80..106	CDD:320455	14/25 (56%)
		TM helix 3	118..148	CDD:320455	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	142..144		1/1 (100%)
		TM helix 4	160..183	CDD:320455	11/22 (50%)
		TM helix 5	201..230	CDD:320455	13/32 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..276		7/49 (14%)
		TM helix 6	303..333	CDD:320455	19/29 (66%)
		TM helix 7	344..369	CDD:320455	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	361..365		2/3 (67%)