DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Htr1a

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_036717.1	Gene:	Htr1a / 24473	RGDID:	2845	Length:	422	Species:	Rattus norvegicus

Alignment Length:	447	Identity:	158/447 - (35%)
Similarity:	227/447 - (50%)	Gaps:	61/447 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 TSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERY 138
            |:|:..|    .|.||..|...|::...:.:.:..:|.|.      |..|.||:.|:.|:..||.
  Rat    12 TTASQEP----FGTGGNVTSISDVTFSYQVITSLLLGTLI------FCAVLGNACVVAAIALERS 66

  Fly   139 LHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVI 203
            |....||.|.||||.|.:|.::|:|.:|||:|| |.|..|...||::.:||||..|:|||:||.|
  Rat    67 LQNVANYLIGSLAVTDLMVSVLVLPMAALYQVL-NKWTLGQVTCDLFIALDVLCCTSSILHLCAI 130

  Fly   204 SLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFTEHLG 268
            :||||||||||..|..:.|.:|||.||:..|:....||.|.::.||...|...|. .||.::..|
  Rat   131 ALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPD-ACTISKDHG 194

  Fly   269 YLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQ 333
            |.::|:..:||:|||:|:..|.||:|||..:.|..   .::|........|       ||:....
  Rat   195 YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKT---VRKVEKKGAGTSL-------GTSSAPP 249

  Fly   334 NQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGT--TTSTPEEPDDE---PLSALHNNGLA 393
            .:.|..|..|.|..             .....|...||  |.....:.|||   .:..:|..|.:
  Rat   250 PKKSLNGQPGSGDW-------------RRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNS 301

  Fly   394 R-------------------HRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVN 439
            :                   .|...:|....||:| .|:|:|..|||||:||.||:||||||:|.
  Rat   302 KEHLPLPSESGSNSYAPACLERKNERNAEAKRKMA-LARERKTVKTLGIIMGTFILCWLPFFIVA 365

  Fly   440 LLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL-CMCCPR 495
            |:..||........::.||:.|||:.||.:||||||.:::||:.||.::: |..|.|
  Rat   366 LVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	79/171 (46%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	136/372 (37%)
Htr1a	NP_036717.1	7tm_4	48..>169	CDD:304433	60/121 (50%)
		7tm_1	53..400	CDD:278431	136/372 (37%)
		Agonist binding. /evidence=ECO:0000250	112..121		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	133..135		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..261		6/32 (19%)
		Agonist binding. /evidence=ECO:0000250	358..362		3/3 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	396..400		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910