Protein Alignment Dop1R2 and Drd2

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_036679.1
• Gene: Drd2 / 24318
• RGDID: 2520
• Length: 444
• Species: Rattus norvegicus
• Alignment Length: 435
• Identity: 144/435 - (33%)
• Similarity: 213/435 - (48%)
• Gaps: 93/435 - (21%)

  Fly   115 LFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGT 179
            |.|..|..||||.||.:||.||:.|.|.|||.|.||||||.||..:|||:....||: ..|.|..
  Rat    41 LTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV-GEWKFSR 104

  Fly   180 DWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVK-RAAGLIAAVWICSSAISFP 243
            ..|||:.:|||:..||||||||.||:|||.|:..|..|..|.:.| |...:||.||:.|..||.|
  Rat   105 IHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCP 169

  Fly   244 AIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTK 308
            .:.........|     |... :..::|:||.:|||:|.:|.:..|.:||  .|::.|..::.||
  Rat   170 LLFGLNNTDQNE-----CIIA-NPAFVVYSSIVSFYVPFIVTLLVYIKIY--IVLRKRRKRVNTK 226

  Fly   309 Q---------------------------VLMASG-----------------ELQLTLRIHRGGTT 329
            :                           |:|.|.                 ||::.:   ...|:
  Rat   227 RSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEM---LSSTS 288

  Fly   330 RDQQNQVSGGGGGGGGGGGGGGSLSHSHSH------SHHHHHNHGGGTTTSTPEEPDDEPLSALH 388
            ..::.:.|              .:..||..      |||..|::     ..:|.:|:....:.:.
  Rat   289 PPERTRYS--------------PIPPSHHQLTLPDPSHHGLHSN-----PDSPAKPEKNGHAKIV 334

  Fly   389 NNGLARHRHM-----GKN----FSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGF 444
            |..:|:...:     ||.    .::||:.....|||||.:.|.||:|||||||||||:.::|:..
  Rat   335 NPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIH 399

  Fly   445 CIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            | :|.....:.||. ||||::||.:||:||..::.:||:||:::|
  Rat   400 C-DCNIPPVLYSAF-TWLGYVNSAVNPIIYTTFNIEFRKAFMKIL 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	138/422 (33%)
		TM helix 2	143..169	CDD:320195	15/25 (60%)
		TM helix 3	182..212	CDD:320195	20/29 (69%)
		TM helix 4	224..246	CDD:320195	10/22 (45%)
		TM helix 5	266..295	CDD:320195	11/28 (39%)
		TM helix 6	297..442	CDD:320195	44/203 (22%)
		TM helix 7	453..478	CDD:320195	12/24 (50%)
Drd2	NP_036679.1	7tmA_D2_dopamine_R	35..438	CDD:320435	141/429 (33%)
		TM helix 1	36..62	CDD:320435	11/20 (55%)
		TM helix 2	69..92	CDD:320435	15/22 (68%)
		TM helix 3	107..137	CDD:320435	20/29 (69%)
		TM helix 4	152..170	CDD:320435	7/17 (41%)
		TM helix 5	186..211	CDD:320435	9/24 (38%)
		Interaction with PPP1R9B. /evidence=ECO:0000269|PubMed:10391935	211..374		32/186 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..329		10/68 (15%)
		TM helix 6	367..397	CDD:320435	19/29 (66%)
		TM helix 7	406..431	CDD:320435	12/25 (48%)