Protein Alignment Dop1R2 and Drd1

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_036678.3
• Gene: Drd1 / 24316
• RGDID: 2518
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 427
• Identity: 146/427 - (34%)
• Similarity: 206/427 - (48%)
• Gaps: 104/427 - (24%)

  Fly    95 PDLSEFLEA-LPND-----RVGLLAFLFLFSFATVFGNSLVILAVIRERYLHT-ATNYFITSLAV 152
            |:.|...|| ||.:     |:....||.|...:|:.||:||..||||.|:|.: .||:|:.||||
  Rat     3 PNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAV 67

  Fly   153 ADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSY 217
            :|.||.::|||:.|:.|: ...|.||: :|:||.:.|::.||||||||||||:||||||:.||.|
  Rat    68 SDLLVAVLVMPWKAVAEI-AGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQY 130

  Fly   218 PMRMTVKRAAGLIAAVWICSSAISF-PAIVWWRAAR-----DGEMPAYKCTFTEHLG------YL 270
            ..:||.|.|..||:..|..|..||| |..:.|..|:     ||...:.:.|..::..      |.
  Rat   131 ERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYA 195

  Fly   271 VFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQ 335
            :.||.||||:|:.:|:.||..|||.|..|.|.:
  Rat   196 ISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRI-------------------------------- 228

  Fly   336 VSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGK 400
                           .:|..:..|:.:.....|.|           .|:....:.         .
  Rat   229 ---------------SALERAAVHAKNCQTTAGNG-----------NPVECAQSE---------S 258

  Fly   401 NFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIE------CIEHEEIVSAIV 459
            :|.:|     |.:|.|..|||.::||||:.||||||:.|.:..||..      ||  :.|...:.
  Rat   259 SFKMS-----FKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCI--DSITFDVF 316

  Fly   460 TWLGWINSCMNPVIYACWSRDFRRAFVRLL-C-MCCP 494
            .|.||.||.:||:||| ::.||::||..|| | ..||
  Rat   317 VWFGWANSSLNPIIYA-FNADFQKAFSTLLGCYRLCP 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	129/381 (34%)
		TM helix 2	143..169	CDD:320195	14/25 (56%)
		TM helix 3	182..212	CDD:320195	21/29 (72%)
		TM helix 4	224..246	CDD:320195	10/22 (45%)
		TM helix 5	266..295	CDD:320195	13/34 (38%)
		TM helix 6	297..442	CDD:320195	26/144 (18%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
Drd1	NP_036678.3	7tm_GPCRs	22..341	CDD:475119	133/395 (34%)
		TM helix 1	25..49	CDD:320443	10/23 (43%)
		TM helix 2	59..81	CDD:320443	12/21 (57%)
		TM helix 3	96..118	CDD:320443	14/21 (67%)
		TM helix 4	141..157	CDD:320443	7/15 (47%)
		TM helix 5	192..215	CDD:320443	10/22 (45%)
		TM helix 6	271..293	CDD:320443	13/21 (62%)
		TM helix 7	310..335	CDD:320443	11/25 (44%)