DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Adrb2

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_036624.2	Gene:	Adrb2 / 24176	RGDID:	2060	Length:	418	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	165/516 - (31%)
Similarity:	219/516 - (42%)	Gaps:	137/516 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PEPDLSEFLEALPNDR----------------VGLLAFLFLFSFATVFGNSLVILAVIRERYLHT 141
            |..:.|:||.| ||..                ||:...:.:...|.||||.|||.|:.:...|.|
  Rat     3 PHGNDSDFLLA-PNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQT 66

  Fly   142 ATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLD 206
            .|||||||||.||.::||.|:||.|.: :|...|.||..||:.|.|:|||..||||..||||::|
  Rat    67 VTNYFITSLACADLVMGLAVVPFGASH-ILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVD 130

  Fly   207 RYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIV--WWRAARDGEMPAYK----CTFTE 265
            ||.|||.||.|...:|..:|..:|..|||.|...||..|.  |:||.....:..|.    |.|..
  Rat   131 RYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKQAIDCYAKETCCDFFT 195

  Fly   266 HLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTR 330
            :..|.:.||.:|||:||:||||.|.|:::.|..|.:.:
  Rat   196 NQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKI--------------------------- 233

  Fly   331 DQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARH 395
                                     ..|....|..|                 ||.:..:|.:.|
  Rat   234 -------------------------DKSEGRFHAQN-----------------LSQVEQDGRSGH 256

  Fly   396 RHMGKNFSLSRKLAKFA-KEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIV 459
            .        .|:.:||. ||.||.|||||:||.|.:||||||:||::.......|..|  |..::
  Rat   257 G--------LRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANLIPKE--VYILL 311

  Fly   460 TWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSF 524
            .|||::||..||:|| |.|.|||.||..|||:  .|...:.|.....|.|..........::...
  Rat   312 NWLGYVNSAFNPLIY-CRSPDFRIAFQELLCL--RRSSSKTYGNGYSSNSNGRTDYTGEQSAYQL 373

  Fly   525 GYHSVNQIDRTLMXRQLSSCSTCSGGS---NCGGSRSAHHQHHSSGTATPS----SSQRSC 578
            |....|::          .|....|..   ||.|:             .||    |..|:|
  Rat   374 GQEKENEL----------LCEEAPGMEGFVNCQGT-------------VPSLSIDSQGRNC 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	85/177 (48%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	125/355 (35%)
Adrb2	NP_036624.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		7/20 (35%)
		7tm_4	48..340	CDD:304433	136/372 (37%)
		7tm_1	50..326	CDD:278431	125/355 (35%)
		PDZ-binding	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3118
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.960