Protein Alignment Dop1R2 and tyra-3

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001024805.1
• Gene: tyra-3 / 187427
• WormBaseID: WBGene00006475
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 180/574 - (31%)
• Similarity: 251/574 - (43%)
• Gaps: 163/574 - (28%)

  Fly    59 LPTSTELVLNATTSATSATLSPAMVATGGG-------GTTTPEPDLSEFLE---ALPNDRVGLLA 113
            ||:||      |.:.||.|::|..||:...       |:.:|   |||:|.   .|....|.:..
 Worm    49 LPSST------TATITSTTVTPVWVASKNSIPFADTLGSNSP---LSEYLPVKLCLGIHDVFIAL 104

  Fly   114 FLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFG 178
            ||.:....|:|||.||:|:|:..:.:.|.||..:||||.||.||||:|||.|.|..:..:.|..|
 Worm   105 FLVMLILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRWPLG 169

  Fly   179 TDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFP 243
            ...|.:|.:.|||..|||||||||||||||:|||.|..||...:.|.||||:.|||..|..:..|
 Worm   170 RFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSP 234

  Fly   244 --AIVWWRAARD-----GEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTR 301
              .|..|....|     |....:||.::..:.|.::|:..|||||||||:|.|.:|:|.|
 Worm   235 PWVIPSWNLFIDNNNNTGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVA----- 294

  Fly   302 SLKIGTKQVLM--ASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSH-HH 363
                ..::.||  :.|..:|:.|:    |...|:||           .....:.|..||.:. ..
 Worm   295 ----SEREALMRQSVGTCRLSNRL----TKTQQKNQ-----------RNNLRTASAPHSRTRVQV 340

  Fly   364 HHNHG------------------------------------------GGTT--------TSTPEE 378
            :||.|                                          .|||        |::|
 Worm   341 NHNCGRVNYSVRPVEYANRVENSLKPSHERFDSTDCEDSPPNGDSLEAGTTCNISMSLVTNSP-- 403

  Fly   379 PD------------------------DEPL--------------------SALHNNGLAR--HRH 397
            |:                        |.|:                    :.|..|.|.:  |.|
 Worm   404 PNGLQKEAKNSMERECHSLADIVNSADTPVRKNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEH 468

  Fly   398 M-----GKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHE---EI 454
            .     ||....|::...:.:|:||.||:|||:..|||||:|||::.|:..|..:.:...   .|
 Worm   469 YQINGPGKAVRGSKEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVFISDPVAESPIYRI 533

  Fly   455 VSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSK 508
            .|....|||:.||.:||:||..::.||||.|..||...|.:..||    ||..|
 Worm   534 TSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLLSFGCVQHHRR----TMSVK 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	150/476 (32%)
		TM helix 2	143..169	CDD:320195	17/25 (68%)
		TM helix 3	182..212	CDD:320195	21/29 (72%)
		TM helix 4	224..246	CDD:320195	10/23 (43%)
		TM helix 5	266..295	CDD:320195	14/28 (50%)
		TM helix 6	297..442	CDD:320195	48/248 (19%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
tyra-3	NP_001024805.1	7tmA_tyramine_R-like	101..>300	CDD:320189	88/207 (43%)
		TM helix 1	101..127	CDD:320189	10/25 (40%)
		TM helix 2	134..160	CDD:320189	17/25 (68%)
		TM helix 3	173..203	CDD:320189	21/29 (72%)
		TM helix 4	215..238	CDD:320189	10/22 (45%)
		TM helix 5	264..289	CDD:320189	13/24 (54%)
		7tm_GPCRs	<486..564	CDD:475119	33/77 (43%)
		TM helix 6	494..516	CDD:320189	13/21 (62%)
		TM helix 7	532..557	CDD:320189	11/24 (46%)