Protein Alignment Dop1R2 and DRD4

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_000788.2
• Gene: DRD4 / 1815
• HGNCID: 3025
• Length: 419
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 137/481 - (28%)
• Similarity: 189/481 - (39%)
• Gaps: 119/481 - (24%)

  Fly    68 NATTSATSATLS---PAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLV 129
            |.:|:.....|:   ||..|:.|...            .|.......|....|...|.:.|||||
Human     3 NRSTADADGLLAGRGPAAGASAGASA------------GLAGQGAAALVGGVLLIGAVLAGNSLV 55

  Fly   130 ILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFST 194
            .::|..||.|.|.||.||.|||.||.|:.|:|:|.....||....|......||...::||:..|
Human    56 CVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT 120

  Fly   195 ASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAY 259
            |||.|||.||:||:.|:..|..|..:...:|...||.|.|:.|:|::.|.:......| |..||.
Human   121 ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVR-GRDPAV 184

  Fly   260 KCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIH 324
             |.. |...|:|:||..||:||..:|:..|...:|.                :...|:....::|
Human   185 -CRL-EDRDYVVYSSVCSFFLPCPLMLLLYWATFRG----------------LQRWEVARRAKLH 231

  Fly   325 RGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDE--PLSAL 387
            .....|.     ||.|                           ....|...|..|.|.  |..|.
Human   232 GRAPRRP-----SGPG---------------------------PPSPTPPAPRLPQDPCGPDCAP 264

  Fly   388 HNNGLAR-------------------------------HRHMGKNF------------------S 403
            ...||.|                               ....|.|.                  :
Human   265 PAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQT 329

  Fly   404 LSRKLAKF-AKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINS 467
            ..|:.||. .:|:||.:.|.:|:|.|::||.|||||::....|..|.....:||| |||||::||
Human   330 RRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSA-VTWLGYVNS 393

  Fly   468 CMNPVIYACWSRDFRRAFVRLLCMCC 493
            .:|||||..::.:||..|.:.|..||
Human   394 ALNPVIYTVFNAEFRNVFRKALRACC 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	122/414 (29%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	16/29 (55%)
		TM helix 4	224..246	CDD:320195	8/21 (38%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	34/196 (17%)
		TM helix 7	453..478	CDD:320195	15/24 (63%)
DRD4	NP_000788.2	7tmA_D4_dopamine_R	38..411	CDD:320434	125/424 (29%)
		TM helix 1	38..62	CDD:320434	9/23 (39%)
		TM helix 2	69..95	CDD:320434	13/25 (52%)
		TM helix 3	108..138	CDD:320434	16/29 (55%)
		TM helix 4	150..173	CDD:320434	8/22 (36%)
		TM helix 5	189..218	CDD:320434	10/28 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..264		10/65 (15%)
		4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P	249..312		10/62 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..336		1/18 (6%)
		TM helix 6	339..369	CDD:320434	14/29 (48%)
		TM helix 7	379..404	CDD:320434	15/25 (60%)