Protein Alignment Dop1R2 and ser-4

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_497452.1
• Gene: ser-4 / 175322
• WormBaseID: WBGene00004779
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 149/459 - (32%)
• Similarity: 220/459 - (47%)
• Gaps: 51/459 - (11%)

  Fly    64 ELVLNATTSATS--ATLSPAMVATGGGGTTTPE--PDLSEFLEAL--PNDRVGLLAFLFLFSFAT 122
            |.:||.|.|.:|  |||..|:..    ||...:  |..:|....:  |..:..:||.:.|....:
 Worm     4 ETLLNLTASPSSQPATLLSAVAR----GTHLVDQFPAHAEIFSDIERPLVQTVILASVLLVLILS 64

  Fly   123 VF-GNSLVILAVIRERYLHTATNYF-ITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIW 185
            .| ||..||||:|.||.|.....|: |.||||||.|||::|.|..|.:.| ..||..|...||.|
 Worm    65 CFIGNLFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLGAWFTV-TGTWNLGVVVCDFW 128

  Fly   186 RSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWR- 249
            .|:|||..|||||:|..|:|||||:||| ..|....|.||...::|.:|..|..||......|:
 Worm   129 ISVDVLVCTASILHLVAIALDRYWSITD-ICYVQNRTPKRITLMLAVIWFTSLLISLAPFAGWKD 192

  Fly   250 -AARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAA------------VIQTR 301
             ...|..:.::.|..::.:.|.|||:..:||:||:.::..|.:|.|||            ||:..
 Worm   193 EGFSDRVLKSHVCLISQQISYQVFSTATAFYIPLIAIICVYWKIMRAAKKRFKRERDRRTVIRPP 257

  Fly   302 SLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHH- 365
            ...|..|:.:|.....:..|      ......:.:...||.||..........|:.|.|.....
 Worm   258 PDAIDEKKAMMPKKSKKCPL------PPAVVISDIQANGGTGGKTNSIKNPPRHNESSSSASEEE 316

  Fly   366 ------NHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIV 424
                  ||..|..|:...:.|:|  :.....|:.:.|...|..:      :..:|:||.:||.|:
 Worm   317 RTMTQTNHAPGDVTTQETKIDEE--NGRSKPGIVKRRRRTKESN------EMKRERKAWRTLAII 373

  Fly   425 MGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            .|.|:.||.|||:|::....| .| :...::..:..|||::||.:||:||..:|:|||.||.|::
 Worm   374 TGTFVACWTPFFLVSIYRPIC-GC-QISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRII 436

  Fly   490 CMCC 493
            ...|
 Worm   437 KRMC 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	127/385 (33%)
		TM helix 2	143..169	CDD:320195	14/26 (54%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	7/21 (33%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	36/151 (24%)
		TM helix 7	453..478	CDD:320195	9/24 (38%)
ser-4	NP_497452.1	7tmA_5-HT1A_invertebrates	52..432	CDD:320454	130/397 (33%)
		TM helix 1	53..79	CDD:320454	11/25 (44%)
		TM helix 2	87..113	CDD:320454	14/25 (56%)
		TM helix 3	125..155	CDD:320454	19/29 (66%)
		TM helix 4	166..188	CDD:320454	7/21 (33%)
		TM helix 5	210..239	CDD:320454	10/28 (36%)
		TM helix 6	361..391	CDD:320454	14/29 (48%)
		TM helix 7	400..425	CDD:320454	9/24 (38%)