DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Htr7

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001334371.1	Gene:	Htr7 / 15566	MGIID:	99841	Length:	470	Species:	Mus musculus

Alignment Length:	525	Identity:	149/525 - (28%)
Similarity:	234/525 - (44%)	Gaps:	138/525 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDDNGSS-PEVEGAEGAGAPLLALLRVDGLNQTQTRSPSPSFFGSYN-ISEDVYFYFNGLPTST 63
            |:|.|.|. |::.|      .|.:|:..:...:.|..||..   |::: :|..:....:|.|
Mouse     1 MMDVNSSGRPDLYG------HLRSLILPEVGRRLQDLSPDG---GAHSVVSSWMPHLLSGFP--- 53

  Fly    64 ELVLNATTSATSATLSPAMVATGGGGTTTPEPD----LSEFLEALPNDRVGLLAFLFLFSFATVF 124
                       ..|.|||       .|....||    ..|.:.....::|.:.:.|.|.:..|:.
Mouse    54 -----------EVTASPA-------PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIA 100

  Fly   125 GNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLD 189
            ||.||:::|...:.|...:||.|.|||:||..|.:.||||.::.:::...|.||..:|:::.::|
Mouse   101 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMD 165

  Fly   190 VLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWW-RAARD 253
            |:..||||:.|||||:|||..||.|.:||:|...|..|.:|.:||:.|::|:.|.:..| :...|
Mouse   166 VMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVND 230

  Fly   254 GEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQ 318
            .::    |..::..||.::|:.::||:|:.||:|.|.:||:||      .|...|
Mouse   231 DKV----CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAA------RKSAAK---------- 275

  Fly   319 LTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEP 383
                                                          |...|        .|..:|
Mouse   276 ----------------------------------------------HKFSG--------FPRVQP 286

  Fly   384 LSALHNNGLAR--------------HRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLP 434
            .|.:..||:.:              .:|..||.|:      |.:|:|||.||||::|.|.:||||
Mouse   287 ESVISLNGVVKLQKEVEECANLSRLLKHERKNISI------FKREQKAATTLGIIVGAFTVCWLP 345

  Fly   435 FFVVN----LLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPR 495
            ||:::    .:.|....||  ...|.....|||:.||.:||.|||.::||.|..: |.|..|..|
Mouse   346 FFLLSTARPFICGTSCSCI--PLWVERTCLWLGYANSLINPFIYAFFNRDLRTTY-RSLLQCQYR 407

  Fly   496 KIRRK 500
            .|.||
Mouse   408 NINRK 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	66/172 (38%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	109/367 (30%)
Htr7	NP_001334371.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870