DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Htr6

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001364025.1	Gene:	Htr6 / 15565	MGIID:	1196627	Length:	440	Species:	Mus musculus

Alignment Length:	462	Identity:	137/462 - (29%)
Similarity:	195/462 - (42%)	Gaps:	120/462 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVIL 131
            :|::|.|......|   |.||.|                    .:.|.|.:....|...|||:|.
Mouse     8 VNSSTPAWGPGPPP---APGGSG--------------------WVAAALCVVIVLTAAANSLLIA 49

  Fly   132 AVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTAS 196
            .:..:..|...:|:|:.||..:|.:||||||| .|:...|...|......|.:|.:.||:..:||
Mouse    50 LICTQPALRNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113

  Fly   197 ILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISF-PAIVWW------RAARDG 254
            |||||:||||||..|..|..|.:|||..||..||...|..::..|| |.::.|      |.:..|
Mouse   114 ILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPG 178

  Fly   255 EMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAA---VIQTRSLKIGTKQVLMASGE 316
            :     |.....|.|::.:|.::|:||...:.||||||..||   .:|..||..||    ..:|:
Mouse   179 Q-----CRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGT----ATAGQ 234

  Fly   317 LQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTP--EEP 379
            ...||::.|                                               |..|  |..
Mouse   235 ALETLQVPR-----------------------------------------------TPRPGMESA 252

  Fly   380 DDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGF 444
            |...|:..|:.                      |..||:.||||::.:|.:.||||||.::....
Mouse   253 DSRRLTTKHSR----------------------KALKASLTLGILLSMFFVTWLPFFVASIAQAV 295

  Fly   445 CIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL-CMCCPRKIRRKYQPTMRSK 508
            | :||...  :..::||||:.||.|||:||..:.|||:||..|.: |:.||.:.|.  .|...|.
Mouse   296 C-DCISPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRA--SPASPSM 355

  Fly   509 SQCHVAA 515
            ...|..|
Mouse   356 WTSHSGA 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	67/178 (38%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	110/360 (31%)
Htr6	NP_001364025.1	7tmA_5-HT6	29..333	CDD:320182	119/385 (31%)
		TM helix 1	29..53	CDD:320182	7/23 (30%)
		TM helix 2	62..84	CDD:320182	12/22 (55%)
		TM helix 3	100..122	CDD:320182	11/21 (52%)
		TM helix 4	145..161	CDD:320182	5/15 (33%)
		TM helix 5	186..209	CDD:320182	8/22 (36%)
		TM helix 6	269..291	CDD:320182	11/21 (52%)
		TM helix 7	301..326	CDD:320182	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910