Protein Alignment Dop1R2 and Htr4

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_032339.2
• Gene: Htr4 / 15562
• MGIID: 109246
• Length: 388
• Species: Mus musculus
• Alignment Length: 460
• Identity: 142/460 - (30%)
• Similarity: 205/460 - (44%)
• Gaps: 134/460 - (29%)

  Fly   107 DRVGLLAFLFLFSFATVFGNSLVILAVIRERYLH-TATNYFITSLAVADCLVGLVVMPFSALYEV 170
            ::|.||.||.:.....:.||.||::||.|:|.|. ..|||||.|||.||.||.::||||.|: |:
Mouse    18 EKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAI-EL 81

  Fly   171 LENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAI-TDPFSYPMRMTVKRAAGLIAAVW 234
            :::.|.:|..:|.:..|||||.:||||.:||.||||||:|| ..|..|..:||..|.|.::...|
Mouse    82 VQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCW 146

  Fly   235 ICSSAISF-PAIVWWRAARDGEMPAYK------------CTFTEHLGYLVFSSTISFYLPLLVMV 286
            :....||| |.:..|.  ..|.:...:            |.|..:..|.:..|.::||:|.|:||
Mouse   147 VLPMFISFLPIMQGWN--NIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMV 209

  Fly   287 FTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGG 351
            ..|.|||..|       |...:|:.|          :.|.|.|.:.:.|
Mouse   210 LAYYRIYVTA-------KEHAQQIQM----------LQRAGATSESRPQ---------------- 241

  Fly   352 SLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKK 416
               .:..||.|                                               :...|.|
Mouse   242 ---PADQHSTH-----------------------------------------------RMRTETK 256

  Fly   417 AAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDF 481
            |||||.::||.|..||.||||.|::..| |:....|::.:|.: |||:|||.:||.:||..::.|
Mouse   257 AAKTLCVIMGCFCFCWAPFFVTNIVDPF-IDYTVPEQVWTAFL-WLGYINSGLNPFLYAFLNKSF 319

  Fly   482 RRAFVRLLCMCCPRKIRRKYQPTM--------------------------RSKSQCHVAAA--MV 518
            ||||  |:.:||..: |.|..|.:                          :.:|:||:.|.  :|
Mouse   320 RRAF--LIILCCDDE-RYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLV 381

  Fly   519 AASTS 523
            ||..|
Mouse   382 AAQPS 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	121/377 (32%)
		TM helix 2	143..169	CDD:320195	17/25 (68%)
		TM helix 3	182..212	CDD:320195	20/30 (67%)
		TM helix 4	224..246	CDD:320195	7/22 (32%)
		TM helix 5	266..295	CDD:320195	12/28 (43%)
		TM helix 6	297..442	CDD:320195	27/144 (19%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
Htr4	NP_032339.2	7tmA_5-HT4	20..323	CDD:320184	126/390 (32%)
		TM helix 1	21..47	CDD:320184	10/25 (40%)
		TM helix 2	55..81	CDD:320184	17/26 (65%)
		TM helix 3	93..123	CDD:320184	19/29 (66%)
		TM helix 4	136..159	CDD:320184	7/22 (32%)
		TM helix 5	189..218	CDD:320184	12/28 (43%)
		TM helix 6	252..282	CDD:320184	17/29 (59%)
		TM helix 7	291..316	CDD:320184	12/25 (48%)