Protein Alignment Dop1R2 and Htr2b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_006529209.1
• Gene: Htr2b / 15559
• MGIID: 109323
• Length: 495
• Species: Mus musculus
• Alignment Length: 514
• Identity: 149/514 - (28%)
• Similarity: 218/514 - (42%)
• Gaps: 98/514 - (19%)

  Fly    45 SYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGG--TTTPEPDLSEFLEALPND 107
            ||.:||.        .|::|.:|..|..        .::.|...|  |.:...::.:.:|. ...
Mouse     4 SYKMSEQ--------STTSEHILQKTCD--------HLILTNRSGLETDSVAEEMKQTVEG-QGH 51

  Fly   108 RVGLLAFLFL-FSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVL 171
            .|...|.|.| ....|:.||.||||||..|:.|..|||||:.|||:||.||||.|||.:.|..:.
Mouse    52 TVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMF 116

  Fly   172 ENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWIC 236
            |..|......|..|..||||||||||::||.||||||.||..|.......:...|...|..||:.
Mouse   117 EAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLI 181

  Fly   237 SSAI-SFPAIVWWRAARDG-EMPA--------------YKCTFT-EHLG-YLVFSSTISFYLPLL 283
            |..: ..|...:.:.|..| .:|.              ..|..| :..| ::||.|..:|:.||.
Mouse   182 SIGMWGMPLFPYGQNASSGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLT 246

  Fly   284 VMVFTYCRIYRAAVIQTRSLKIGTK--QVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGG 346
            :||.||  ......:|.::..:..|  |.|.......:.||.....::.::...:.|
Mouse   247 IMVVTY--FLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDG-------- 301

  Fly   347 GGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKF 411
                       ||......|            ..||.|       :.|...:||     |.....
Mouse   302 -----------SHRDKILPN------------SSDETL-------MRRMSSVGK-----RSAQTI 331

  Fly   412 AKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHE-EIVSAIVTWLGWINSCMNPVIYA 475
            :.|::|:|.||:|..:|::.|.|||:.||....|..|.:.. :.:..|..|:|:::|.:||:||.
Mouse   332 SNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYT 396

  Fly   476 CWSRDFRRAFVRLLCMCCPR-----KIRRKYQPTMRSKSQCHVAAAMVAASTSFGYHSV 529
            .:::.||.||.|.: .|..|     |..||:..|:     | ...:||..|..|..|.:
Mouse   397 LFNKTFREAFGRYI-TCNYRATKSVKALRKFSSTL-----C-FGNSMVENSKFFTKHGI 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	118/383 (31%)
		TM helix 2	143..169	CDD:320195	17/25 (68%)
		TM helix 3	182..212	CDD:320195	21/29 (72%)
		TM helix 4	224..246	CDD:320195	6/22 (27%)
		TM helix 5	266..295	CDD:320195	11/29 (38%)
		TM helix 6	297..442	CDD:320195	30/146 (21%)
		TM helix 7	453..478	CDD:320195	8/24 (33%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:475119	124/404 (31%)
		TM helix 1	56..80	CDD:410628	12/23 (52%)
		TM helix 2	89..111	CDD:410628	15/21 (71%)
		TM helix 3	128..150	CDD:410628	14/21 (67%)
		TM helix 4	173..205	CDD:410628	7/31 (23%)
		TM helix 5	230..253	CDD:410628	11/24 (46%)
		TM helix 6	338..360	CDD:410628	9/21 (43%)
		TM helix 7	374..399	CDD:410628	8/24 (33%)