Protein Alignment Dop1R2 and Htr1f

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_032336.1
• Gene: Htr1f / 15557
• MGIID: 99842
• Length: 366
• Species: Mus musculus
• Alignment Length: 403
• Identity: 140/403 - (34%)
• Similarity: 202/403 - (50%)
• Gaps: 67/403 - (16%)

  Fly    99 EFLEALPNDRVGLLAFLFLFSFA--TVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVV 161
            |.|..:|:.   :|..|.|...|  |...|||||.|:|..|.||...||.|.||||.|.||.::|
Mouse    15 ELLNRMPSK---ILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLV 76

  Fly   162 MPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRA 226
            ||||.:| ::..:|..|...||||.|:|::..|.|||:|..|:||||.||||...|..:.|.:.|
Mouse    77 MPFSIVY-IVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRHA 140

  Fly   227 AGLIAAVWICSSAISFPAIVWWR--AARDGEMPAYKCTFT-EHLGYLVFSSTISFYLPLLVMVFT 288
            ..:|..||:.|..||.|.:.|..  .:||.|     |... :|:...::|:..:||:||::::..
Mouse   141 GIMITIVWVISVFISMPPLFWRHQGTSRDDE-----CVIKHDHIVSTIYSTFGAFYIPLVLILIL 200

  Fly   289 YCRIYRAAVI------QTRSLKIGTK-QVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGG 346
            |.:|||||..      .:|.:|.... ||.:.|||..:.|     .:|.....:
Mouse   201 YYKIYRAARTLYHKRQASRMIKEELNGQVFLESGEKSIKL-----VSTSYMLEK----------- 249

  Fly   347 GGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKF 411
                 |||...:.....|         ||.:.|..|   ..|.....|.:..|
Mouse   250 -----SLSDPSTDFDRIH---------STVKSPRSE---LKHEKSWRRQKISG------------ 285

  Fly   412 AKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYAC 476
            .:|:|||.|||:::|.|:||||||||..|:...|.:|...|| :|..:.|||::||.:||:||..
Mouse   286 TRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEE-MSNFLAWLGYLNSLINPLIYTI 349

  Fly   477 WSRDFRRAFVRLL 489
            ::.||::||.:|:
Mouse   350 FNEDFKKAFQKLV 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	130/372 (35%)
		TM helix 2	143..169	CDD:320195	15/25 (60%)
		TM helix 3	182..212	CDD:320195	17/29 (59%)
		TM helix 4	224..246	CDD:320195	8/21 (38%)
		TM helix 5	266..295	CDD:320195	9/28 (32%)
		TM helix 6	297..442	CDD:320195	38/151 (25%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
Htr1f	NP_032336.1	7tmA_5-HT1F	24..359	CDD:320456	135/386 (35%)
		TM helix 1	25..51	CDD:320456	12/25 (48%)
		TM helix 2	58..84	CDD:320456	16/26 (62%)
		TM helix 3	96..126	CDD:320456	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	8/21 (38%)
		TM helix 5	178..207	CDD:320456	9/28 (32%)
		TM helix 6	286..316	CDD:320456	18/29 (62%)
		TM helix 7	326..351	CDD:320456	12/25 (48%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)