DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop1R2 and Htr1b

DIOPT Version :10

Sequence 1:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster
Sequence 2:NP_034612.1 Gene:Htr1b / 15551 MGIID:96274 Length:386 Species:Mus musculus


Alignment Length:485 Identity:157/485 - (32%)
Similarity:223/485 - (45%) Gaps:103/485 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 EVEGAEGAGAPLLALLRVDGLNQTQTRSPSPSFFGSYNISEDVYFYFNGLPTSTELVLNATTSAT 74
            |.:|.:.|..|..|         :||..|..:.  |:|.|.|.|.|.:.:               
Mouse     2 EEQGIQCAPPPPAA---------SQTGVPLTNL--SHNCSADGYIYQDSI--------------- 40

  Fly    75 SATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYL 139
                                        ||| .:|.|:|.|.|.:.||...|:.||..|.|.|.|
Mouse    41 ----------------------------ALP-WKVLLVALLALITLATTLSNAFVIATVYRTRKL 76

  Fly   140 HTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVIS 204
            ||..||.|.||||.|.||.::|||.|.:|.| ...|..|...||.|.|.|:...||||::||||:
Mouse    77 HTPANYLIASLAVTDLLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASIMHLCVIA 140

  Fly   205 LDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKC-TFTEHLG 268
            |||||||||...|..:.|.||||.:|..||:.|.:||.|...|.:|..:.||  ..| ..|:|:.
Mouse   141 LDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEM--LDCFVNTDHVL 203

  Fly   269 YLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQ 333
            |.|:|:..:||||.|:::..|.|||    ::.||..:  ||....:|:     |:.|.....|..
Mouse   204 YTVYSTVGAFYLPTLLLIALYGRIY----VEARSRIL--KQTPNKTGK-----RLTRAQLITDSP 257

  Fly   334 NQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHM 398
                          |...|::..:|.:               |:.|.:.......|....|    
Mouse   258 --------------GSTSSVTSINSRA---------------PDVPSESGSPVYVNQVKVR---- 289

  Fly   399 GKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLG 463
            ..:..|.:|....|:|:||.|||||::|.||:||||||:::|:...|.:.......:.....|||
Mouse   290 VSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLG 354

  Fly   464 WINSCMNPVIYACWSRDFRRAFVRLLCMCC 493
            ::||.:||:||...:.||::||.:|:...|
Mouse   355 YLNSLINPIIYTMSNEDFKQAFHKLIRFKC 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R2NP_001263072.1 7tmA_Dop1R2-like 122..485 CDD:320195 130/363 (36%)
TM helix 2 143..169 CDD:320195 14/25 (56%)
TM helix 3 182..212 CDD:320195 19/29 (66%)
TM helix 4 224..246 CDD:320195 11/21 (52%)
TM helix 5 266..295 CDD:320195 13/28 (46%)
TM helix 6 297..442 CDD:320195 36/144 (25%)
TM helix 7 453..478 CDD:320195 9/24 (38%)
Htr1bNP_034612.1 7tmA_5-HT1B_1D 42..376 CDD:320455 138/381 (36%)
TM helix 1 47..73 CDD:320455 10/25 (40%)
TM helix 2 80..106 CDD:320455 14/25 (56%)
TM helix 3 118..148 CDD:320455 19/29 (66%)
DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 142..144 1/1 (100%)
TM helix 4 160..183 CDD:320455 11/22 (50%)
TM helix 5 201..230 CDD:320455 13/32 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 255..278 6/51 (12%)
TM helix 6 303..333 CDD:320455 19/29 (66%)
TM helix 7 344..369 CDD:320455 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 361..365 2/3 (67%)

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