DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dop1R2 and Htr1a

DIOPT Version :9

Sequence 1:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster
Sequence 2:NP_032334.2 Gene:Htr1a / 15550 MGIID:96273 Length:421 Species:Mus musculus


Alignment Length:446 Identity:158/446 - (35%)
Similarity:229/446 - (51%) Gaps:56/446 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 NATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILA 132
            |.|||     |.|    .|.||..|...:::...:.:.:..:|.|.      |..|.||:.|:.|
Mouse    11 NTTTS-----LEP----FGTGGNDTGLSNVTFSYQVITSLLLGTLI------FCAVLGNACVVAA 60

  Fly   133 VIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASI 197
            :..||.|....||.|.||||.|.:|.::|:|.:|||:|| |.|..|...||::.:||||..|:||
Mouse    61 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVL-NKWTLGQVTCDLFIALDVLCCTSSI 124

  Fly   198 LNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCT 262
            |:||.|:||||||||||..|..:.|.:|||.||:..|:....||.|.::.||...|...| .:||
Mouse   125 LHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNP-NECT 188

  Fly   263 FTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSL--KIGTKQVLMASG-------ELQ 318
            .::..||.::|:..:||:|||:|:..|.||:|||..:.|..  |:..|....:.|       :..
Mouse   189 ISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKS 253

  Fly   319 LTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHG-------GGTTTSTP 376
            |..:...|...|..:|:..|.....|....|....:......|...::.|       .|.|:..|
Mouse   254 LNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVP 318

  Fly   377 ---EEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVV 438
               |..::....|                  .||:| .|:|:|..|||||:||.||:||||||:|
Mouse   319 ACLERKNERTAEA------------------KRKMA-LARERKTVKTLGIIMGTFILCWLPFFIV 364

  Fly   439 NLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL-CMCC 493
            .|:..||.......|::.||:.|||:.||.:||||||.:::||:.||.::: |..|
Mouse   365 ALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC 420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R2NP_001263072.1 7tm_4 123..>295 CDD:304433 79/171 (46%)
7tm_1 125..474 CDD:278431 135/367 (37%)
Htr1aNP_032334.2 7tm_4 48..>169 CDD:304433 60/121 (50%)
7tm_1 53..400 CDD:278431 135/367 (37%)
Agonist binding. /evidence=ECO:0000250 112..121 4/8 (50%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 133..135 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..268 4/30 (13%)
Agonist binding. /evidence=ECO:0000250 358..362 3/3 (100%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 396..400 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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