Protein Alignment Dop1R2 and Hrh2

DIOPT Version :9

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_036013748.1
• Gene: Hrh2 / 15466
• MGIID: 108482
• Length: 421
• Species: Mus musculus
• Alignment Length: 488
• Identity: 147/488 - (30%)
• Similarity: 208/488 - (42%)
• Gaps: 130/488 - (26%)

  Fly   108 RVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLE 172
            :|.:...|....|.||.||.:|.|||...|.|.:.||.||.|||..|.|:||:||||||:|: |.
Mouse    18 KVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQ-LS 81

  Fly   173 NTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICS 237
            ..|.||..:|:|:.||||:..|||||||.:||||||.|:|||..||:.:|..|.|..:..:|:.|
Mouse    82 FKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVIS 146

  Fly   238 SAISFPAI-VWW--RAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQ 299
            ..:||.:| :.|  |....|....:||....:..|.:....::||||||:|..||.||::.|
Mouse   147 ITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIA--- 208

  Fly   300 TRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHH 364
                                          |:|..::
Mouse   209 ------------------------------REQAKRI---------------------------- 215

  Fly   365 HNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFI 429
             ||                                    :|...|...:|.||..||..|||.||
Mouse   216 -NH------------------------------------ISSWKAATIREHKATVTLAAVMGAFI 243

  Fly   430 ICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCP 494
            :||.|:|...:..|...:...: |:|..||.|||:.||.:||::||..:||||.|:.:|  ..|.
Mouse   244 VCWFPYFTAFVYRGLRGDDAVN-EVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQL--FHCK 305

  Fly   495 RKIRRKYQPTMR------SKSQCHVA--------AAMVAASTSFGYHSVNQIDRTLMXRQLSSCS 545
            ......::.::|      |:||....        ...|.:.|...:...:.:.:|.:     ||:
Mouse   306 LASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRKTAL-----SCT 365

  Fly   546 TCSGG-SNCGGS--RSAHHQHHSSGTATPSSSQ 575
            .||.. .:|..|  |....|.|..|   ||..|
Mouse   366 ICSNNLLSCCKSLWRLRFLQQHPEG---PSKEQ 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	81/174 (47%)
		7tm_1	125..474	CDD:278431	113/351 (32%)
Hrh2	XP_036013748.1	7tmA_Histamine_H2R	19..298	CDD:320179	124/378 (33%)
		TM helix 1	21..45	CDD:320179	10/23 (43%)
		TM helix 2	54..76	CDD:320179	14/21 (67%)
		TM helix 3	92..114	CDD:320179	13/21 (62%)
		TM helix 4	137..153	CDD:320179	4/15 (27%)
		TM helix 5	179..202	CDD:320179	9/22 (41%)
		TM helix 6	232..254	CDD:320179	11/21 (52%)
		TM helix 7	266..291	CDD:320179	13/24 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910