Protein Alignment Dop1R2 and ADRA2A

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_000672.3
• Gene: ADRA2A / 150
• HGNCID: 281
• Length: 465
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 155/477 - (32%)
• Similarity: 213/477 - (44%)
• Gaps: 98/477 - (20%)

  Fly    68 NATTSATSATLSPAMVATGGGGTTTP-EPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVIL 131
            ||:.:.|.        |.|||...|| ...::..|..|    .|||..|      |||||.|||:
Human    25 NASWNGTE--------APGGGARATPYSLQVTLTLVCL----AGLLMLL------TVFGNVLVII 71

  Fly   132 AVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTAS 196
            ||...|.|....|.|:.|||.||.||..:|:|||...||: ..|:||..||:|:.:|||||.|:|
Human    72 AVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKAWCEIYLALDVLFCTSS 135

  Fly   197 ILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAI--VWWRAARDGEMPAY 259
            |::||.|||||||:||....|.::.|.:|...:|..||:.|:.||||.:  :..:....|..||.
Human   136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAE 200

  Fly   260 -KCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTR--SLKIGTKQVLMASGELQLTL 321
             :|...:...|::.|...||:.|.|:|:..|.|||:.|..:||  ..:.|...|....
Human   201 PRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPP------- 258

  Fly   322 RIHRGGTTRDQQNQVSGGGGGGGGG----------GGGGG-----------SLSHSHSHSHHHHH 365
                |||.| :.|.:......|.||          .|..|           :|....|.|..|..
Human   259 ----GGTER-RPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAE 318

  Fly   366 NHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRK--------------------LAK 410
            ...|      |..|:..|    ...|.||...:....||.|:                    .||
Human   319 RPPG------PRRPERGP----RGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAK 373

  Fly   411 FA-------KEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSC 468
            .:       :||:....|.:|:|||::||.|||....|:  .:.|.....:.. ...|.|:.||.
Human   374 ASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLT--AVGCSVPRTLFK-FFFWFGYCNSS 435

  Fly   469 MNPVIYACWSRDFRRAFVRLLC 490
            :|||||..::.||||||.::||
Human   436 LNPVIYTIFNHDFRRAFKKILC 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	136/415 (33%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	9/23 (39%)
		TM helix 5	266..295	CDD:320195	11/28 (39%)
		TM helix 6	297..442	CDD:320195	42/194 (22%)
		TM helix 7	453..478	CDD:320195	9/24 (38%)
ADRA2A	NP_000672.3	7tmA_alpha2A_AR	49..452	CDD:320445	142/438 (32%)
		TM helix 1	50..76	CDD:320445	16/35 (46%)
		TM helix 2	83..109	CDD:320445	13/25 (52%)
		TM helix 3	121..151	CDD:320445	19/29 (66%)
		TM helix 4	163..186	CDD:320445	9/22 (41%)
		TM helix 5	208..237	CDD:320445	11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..368		28/147 (19%)
		PHA03307	244..>389	CDD:223039	30/166 (18%)
		TM helix 6	382..412	CDD:320445	12/29 (41%)
		TM helix 7	420..445	CDD:320445	9/25 (36%)