Protein Alignment Dop1R2 and ADRA1B

DIOPT Version :9

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_011532737.1
• Gene: ADRA1B / 147
• HGNCID: 278
• Length: 556
• Species: Homo sapiens
• Alignment Length: 672
• Identity: 204/672 - (30%)
• Similarity: 287/672 - (42%)
• Gaps: 203/672 - (30%)

  Fly    68 NATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILA 132
            ||..:..:.|.|         .:|.|:.|::..:.      |||:...|:. ||.| ||.||||:
Human    22 NANFTGPNQTSS---------NSTLPQLDITRAIS------VGLVLGAFIL-FAIV-GNILVILS 69

  Fly   133 VIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASI 197
            |...|:|.|.|||||.:||:||.|:...|:||||..||| ..|..|..:||||.::|||..||||
Human    70 VACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVL-GYWVLGRIFCDIWAAVDVLCCTASI 133

  Fly   198 LNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWR--AARDGEMPAYK 260
            |:||.||:|||..:.....||..:|.::|...:.:||:.|:.||...::.|:  |..|.:    :
Human   134 LSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDK----E 194

  Fly   261 CTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHR 325
            |..||...|.:|||..|||:||.|::..|||:|..|...|::|:.|..:.:  |...:|||||
Human   195 CGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEM--SNSKELTLRI-- 255

  Fly   326 GGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNN 390
                                             ||.:.|.:     |.|:.:.....|.|
Human   256 ---------------------------------HSKNFHED-----TLSSTKAKGHNPRS----- 277

  Fly   391 GLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFF------------------- 436
                        |::.||.||::|||||||||||:|:||:||||||
Human   278 ------------SIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLDPDSPPPTHLRVVP 330

  Fly   437 -------VVNL---------LSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAF 485
                   ::||         .||.....::..:.|..:|.|||:.|||:||:||.|.|::|:|||
Human   331 APWGHSSIMNLPLVLPLDATRSGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF 395

  Fly   486 VRLL-CMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFGYHSVNQIDRTLMXRQLSSCS---- 545
            ||:| |.|..|..||:.:                                    |:|..|:
Human   396 VRILGCQCRGRGRRRRRR-----------------------------------RRRLGGCAYTYR 425

  Fly   546 TCSGGSNCGGSRSAHHQHHSSGTATPSSSQRSCTRCQSFHRHHHRSRRRSSGMQMRGDYNSTTAV 610
            ..:.|.:...|:|.......||:.. |.|||:..           |...|.|...||
Human   426 PWTRGGSLERSQSRKDSLDDSGSCL-SGSQRTLP-----------SASPSPGYLGRG-------- 470

  Fly   611 NSALAKTIVTISAPPVAAASASSLHL------GVGGRPSS--VSTLTIASVP--PTLSGSGSPGG 665
                |...|.:.|.|...|..:.|.|      |..||..|  :.|..:.:.|  |...|..|.||
Human   471 ----APPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGG 531

  Fly   666 SVSGA-----------TTPLAP 676
            ..:.|           ..||||
Human   532 CEAAADVANGQPGFKSNMPLAP 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	79/173 (46%)
		7tm_1	125..474	CDD:278431	134/385 (35%)
ADRA1B	XP_011532737.1	7tm_4	57..>181	CDD:304433	61/126 (48%)
		7tm_1	62..384	CDD:278431	134/385 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BB8F
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001183
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107917
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.710