DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and ADRA1D

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_000669.1	Gene:	ADRA1D / 146	HGNCID:	280	Length:	572	Species:	Homo sapiens

Alignment Length:	395	Identity:	159/395 - (40%)
Similarity:	212/395 - (53%)	Gaps:	67/395 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 VGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLEN 173
            ||:..||..|....|.||.||||:|...|:|.|.|||||.:|||||.|:...|:||||..||| .
Human    97 VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVL-G 160

  Fly   174 TWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSS 238
            .|.||..:||:|.::|||..|||||:||.||:|||..:.....||..||.::||.::|.:|:.:.
Human   161 FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVAL 225

  Fly   239 AISFPAIVWWRAARDGEMPAYK--CTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTR 301
            .:|...::.|:.    .:|..:  |..||..||.||||..|||||:.|:|..|||:|..|...||
Human   226 VVSVGPLLGWKE----PVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTR 286

  Fly   302 SLKIGTKQVLMASGELQLTLRIH-RGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHH 365
            ||:.|.|:....:.|  :.|||| ||..|                |..|...:..:..|:...
Human   287 SLEAGVKRERGKASE--VVLRIHCRGAAT----------------GADGAHGMRSAKGHTFRS-- 331

  Fly   366 NHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFII 430
                                                 |||.:|.||::||||||||.||:|||::
Human   332 -------------------------------------SLSVRLLKFSREKKAAKTLAIVVGVFVL 359

  Fly   431 CWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL-CMCCP 494
            ||.|||.| |..|.....::..|.|..::.|||:.|||:||:||.|.||:|:|||:||| |.|..
Human   360 CWFPFFFV-LPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRR 423

  Fly   495 RKIRR 499
            |:.||
Human   424 RRRRR 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	82/173 (47%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	136/351 (39%)
ADRA1D	NP_000669.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		7tmA_alpha1D_AR	97..413	CDD:320450	149/378 (39%)
		TM helix 1	98..124	CDD:320450	12/25 (48%)
		TM helix 2	131..157	CDD:320450	16/25 (64%)
		TM helix 3	169..199	CDD:320450	18/29 (62%)
		TM helix 4	211..234	CDD:320450	5/22 (23%)
		TM helix 5	251..280	CDD:320450	17/28 (61%)
		TM helix 6	341..371	CDD:320450	20/30 (67%)
		TM helix 7	381..406	CDD:320450	13/24 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BB8F
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001183
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910