Protein Alignment Dop1R2 and Drd4

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_031904.1
• Gene: Drd4 / 13491
• MGIID: 94926
• Length: 387
• Species: Mus musculus
• Alignment Length: 399
• Identity: 124/399 - (31%)
• Similarity: 176/399 - (44%)
• Gaps: 89/399 - (22%)

  Fly   125 GNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLD 189
            |||||.::|..||.|.|.|||||.|||.||.|:.::|:|.....||....|......||...::|
Mouse    48 GNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMD 112

  Fly   190 VLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARD- 253
            |:..||||.|||.||:||:.|:|.|..|..:...:..  ||||.|:.|:|::.|.:.   ...|
Mouse   113 VMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLL--LIAATWLLSAAVASPVVC---GLNDV 172

  Fly   254 -GEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGEL 317
             |..||..|  .|:..|:|:||..||:||..:|:..|...:|.
Mouse   173 PGRDPAVCC--LENRDYVVYSSVCSFFLPCPLMLLLYWATFRG---------------------- 213

  Fly   318 QLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEE---- 378
                 :.|....|                        |:..||.......|.|...|.|.:
Mouse   214 -----LRRWEAAR------------------------HTKLHSRAPRRPSGPGPPVSDPTQGPFF 249

  Fly   379 PD-DEPLSALHNNGLARHR----------------------HMGKNFSLSRKLAKF-AKEKKAAK 419
            || ..||.:|..:.....|                      ...:..|..|:.||. .:|:||.:
Mouse   250 PDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMR 314

  Fly   420 TLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRA 484
            .|.:|:|.|::||.|||||::....|..|.....:||| |||||::||.:||:||..::.:||..
Mouse   315 VLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSA-VTWLGYVNSALNPIIYTIFNAEFRSV 378

  Fly   485 FVRLLCMCC 493
            |.:.|.:.|
Mouse   379 FRKTLRLRC 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	121/389 (31%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	16/29 (55%)
		TM helix 4	224..246	CDD:320195	8/21 (38%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	33/172 (19%)
		TM helix 7	453..478	CDD:320195	14/24 (58%)
Drd4	NP_031904.1	7tm_GPCRs	42..379	CDD:475119	121/389 (31%)
		TM helix 2	67..89	CDD:410628	12/21 (57%)
		TM helix 3	106..128	CDD:410628	11/21 (52%)
		TM helix 4	149..165	CDD:410628	7/17 (41%)
		TM helix 5	185..208	CDD:410628	9/22 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..247		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..306		4/18 (22%)
		TM helix 6	313..335	CDD:410628	11/21 (52%)
		TM helix 7	347..372	CDD:410628	14/25 (56%)