Protein Alignment Dop1R2 and Drd3

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_006521840.1
• Gene: Drd3 / 13490
• MGIID: 94925
• Length: 478
• Species: Mus musculus
• Alignment Length: 432
• Identity: 142/432 - (32%)
• Similarity: 205/432 - (47%)
• Gaps: 92/432 - (21%)

  Fly   121 ATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIW 185
            |.:|||.||..||:|||.|.|.|||.:.||||||.||..:|||:....||....|.|....||::
Mouse    74 AIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVF 138

  Fly   186 RSLDVLFSTASILNLCVISLDRYWAITDPFSYPM---RMTVKRAAGLIAAVWICSSAISFPAIVW 247
            .:|||:..||||||||.||:|||.|:..|..|..   :.:.:|.|.:|.|||:.:.|:|.|.:..
Mouse   139 VTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFG 203

  Fly   248 WRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQ--- 309
            :....|..:    |:.: :..::::||.:|||:|..|.|..|.||| ..:.|.|..:|.|:|
Mouse   204 FNTTGDPSI----CSIS-NPDFVIYSSVVSFYVPFGVTVLVYARIY-MVLRQRRRKRILTRQNSQ 262

  Fly   310 -VLMASGELQLT--LRIH-------RGGTTRDQQNQVSGGGGGGGGGGGGGGSLSH--------- 355
             :.:..|..|.:  ||:|       |.....|                 ..|.:.|
Mouse   263 CISIRPGFPQQSSCLRLHPIRQFSIRARFLSD-----------------ATGQMEHIEDKPYPQK 310

  Fly   356 ------SH--------SHS--------------HHHHHNHGGGTT----TSTPEEPDDEPLSALH 388
                  ||        :|.              .|.:...|||.:    |.....|...|..:|.
Mouse   311 CQDPLLSHLQPLSPGQTHGELKRYYSICQDTALRHPNFEGGGGMSQVERTRNSLSPTMAPKLSLE 375

  Fly   389 NNGLARHRHMGKNFSLSRKLAKF------AKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIE 447
            ...|:..|     .|.|.||...      .:||||.:.:.||:|.||:||||||:.::|:..|..
Mouse   376 VRKLSNGR-----LSTSLKLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQA 435

  Fly   448 CIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            |....|:..| .||||::||.:|||||..::.:||:||:::|
Mouse   436 CHVSPELYRA-TTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	138/425 (32%)
		TM helix 2	143..169	CDD:320195	14/25 (56%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	9/21 (43%)
		TM helix 5	266..295	CDD:320195	12/28 (43%)
		TM helix 6	297..442	CDD:320195	46/204 (23%)
		TM helix 7	453..478	CDD:320195	13/24 (54%)
Drd3	XP_006521840.1	7tmA_D3_dopamine_R	62..472	CDD:320436	139/426 (33%)
		TM helix 1	63..89	CDD:320436	8/14 (57%)
		TM helix 2	96..119	CDD:320436	14/22 (64%)
		TM helix 3	135..165	CDD:320436	19/29 (66%)
		TM helix 4	182..200	CDD:320436	7/17 (41%)
		TM helix 5	217..242	CDD:320436	9/24 (38%)
		TM helix 6	400..430	CDD:320436	15/29 (52%)
		TM helix 7	440..465	CDD:320436	13/25 (52%)