Protein Alignment Dop1R2 and TAAR1

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_612200.1
• Gene: TAAR1 / 134864
• HGNCID: 17734
• Length: 339
• Species: Homo sapiens
• Alignment Length: 394
• Identity: 112/394 - (28%)
• Similarity: 174/394 - (44%)
• Gaps: 104/394 - (26%)

  Fly   106 ND-RVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYE 169
            || |..|.:.:.|....|:.||.:||:::...:.|||.||:.|.|:|..|.|:|.:|||:| :..
Human    20 NDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYS-MVR 83

  Fly   170 VLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVW 234
            ..|:.|:||..:|.|..|.|::.|:|||.:|..||:|||:|:.||..|..:|.:.....:|...|
Human    84 SAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISW 148

  Fly   235 ICSSAISFPAIVWWRAARDGEMPAYK-------CT--FTEHLGYLVFSSTISFYLPLLVMVFTYC 290
            ...:..:|..|......:..|...||       |:  |::..|.|.|.:  |||:|..:|:..|.
Human   149 SVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMT--SFYIPGSIMLCVYY 211

  Fly   291 RIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSH 355
            |||..|..|.|.:.       .|:.:||:.|.:
Human   212 RIYLIAKEQARLIS-------DANQKLQIGLEM-------------------------------- 237

  Fly   356 SHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKT 420
                                             .||:::                 :||:||.||
Human   238 ---------------------------------KNGISQ-----------------SKERKAVKT 252

  Fly   421 LGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAF 485
            ||||||||:|||.|||:..::..|....|  ...::.::.|.|::||..||::||.:...||:|.
Human   253 LGIVMGVFLICWCPFFICTVMDPFLHYII--PPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKAL 315

  Fly   486 VRLL 489
            ..:|
Human   316 KMML 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	105/371 (28%)
		TM helix 2	143..169	CDD:320195	12/25 (48%)
		TM helix 3	182..212	CDD:320195	15/29 (52%)
		TM helix 4	224..246	CDD:320195	3/21 (14%)
		TM helix 5	266..295	CDD:320195	12/28 (43%)
		TM helix 6	297..442	CDD:320195	28/144 (19%)
		TM helix 7	453..478	CDD:320195	8/24 (33%)
TAAR1	NP_612200.1	7tmA_TAAR1	26..315	CDD:320438	107/382 (28%)
		TM helix 1	26..51	CDD:320438	7/24 (29%)
		TM helix 2	58..84	CDD:320438	12/26 (46%)
		TM helix 3	96..126	CDD:320438	15/29 (52%)
		TM helix 4	138..161	CDD:320438	4/22 (18%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465	175..186		1/10 (10%)
		TM helix 5	187..216	CDD:320438	12/30 (40%)
		TM helix 6	244..274	CDD:320438	20/29 (69%)
		TM helix 7	283..308	CDD:320438	8/24 (33%)