Protein Alignment Dop1R2 and TAAR9

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 397
• Identity: 112/397 - (28%)
• Similarity: 168/397 - (42%)
• Gaps: 112/397 - (28%)

  Fly   105 PNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYE 169
            |..|..|.|.|...:....|||.||::|::..:.|||.||:.|.|||.||.|||:.|||||.:..
Human    29 PGPRSILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRS 93

  Fly   170 VLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVW 234
            | |:.|:||..:|......|..|..||:.:||.||:|||.|:|||.:||.:.||..:...|...|
Human    94 V-ESCWYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSW 157

  Fly   235 ICSSAISFPAIVWWRAARDG---EMPAYKCT------FTEHLGYLVFSSTISFYLPLLVMVFTYC 290
            ..|...|| :|.:..|..:|   .:.|..|.      ..::...|.|   :.|::|.:.|||.|.
Human   158 FFSVTYSF-SIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCF---LLFFIPNVAMVFIYS 218

  Fly   291 RIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSH 355
            :|:..|..|.|.::
Human   219 KIFLVAKHQARKIE--------------------------------------------------- 232

  Fly   356 SHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKT 420
                            :|::..:...|                    |...::||  :|:|||||
Human   233 ----------------STASQAQSSSE--------------------SYKERVAK--RERKAAKT 259

  Fly   421 LGIVMGVFIICWLPFF---VVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFR 482
            |||.|..|::.|||:.   |::....|......:|     |:.|..:.||.|||:|||.:.:.|.
Human   260 LGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYE-----ILVWCVYYNSAMNPLIYAFFYQWFG 319

  Fly   483 RAFVRLL 489
            :| ::|:
Human   320 KA-IKLI 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	105/374 (28%)
		TM helix 2	143..169	CDD:320195	16/25 (64%)
		TM helix 3	182..212	CDD:320195	13/29 (45%)
		TM helix 4	224..246	CDD:320195	5/21 (24%)
		TM helix 5	266..295	CDD:320195	9/28 (32%)
		TM helix 6	297..442	CDD:320195	22/147 (15%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	109/388 (28%)
		TM helix 1	34..60	CDD:320439	9/25 (36%)
		TM helix 2	67..93	CDD:320439	16/25 (64%)
		TM helix 3	105..135	CDD:320439	13/29 (45%)
		TM helix 4	147..170	CDD:320439	6/23 (26%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		2/12 (17%)
		TM helix 5	194..223	CDD:320439	9/31 (29%)
		TM helix 6	251..281	CDD:320439	16/31 (52%)
		TM helix 7	290..315	CDD:320439	11/29 (38%)