Protein Alignment Dop1R2 and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_061500179.1
• Gene: 5-HT2A / 1269329
• VectorBaseID: AGAMI1_010455
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 623
• Identity: 176/623 - (28%)
• Similarity: 251/623 - (40%)
• Gaps: 157/623 - (25%)

  Fly    14 AEGAGAPLLALLRVDGLNQTQTRSPSPSFFG-------SYNISEDVYFYFNGLPTSTELVLNATT 71
            |.....|:.::..|.|...|::...:.|.|.       |.::.|.:..:.|     .|| .||..
Mosquito   214 ARAVPGPVQSVRLVCGNVSTESPLAAGSLFESDAFELVSVSLLEPIQCWMN-----VEL-RNALV 272

  Fly    72 SAT--SATLSPAMVATGG------------GGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFAT 122
            |.|  :.....|:.|..|            ||.|.|......||            |:.||.||.
Mosquito   273 SPTWLNGAEHHAVAALAGWNQTQLLGELPAGGDTAPGRYEWSFL------------FVILFIFAG 325

  Fly   123 VFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRS 187
            ..||.||.|||..:|.|...||||:.|||:||.||.|.|||..|:...| ..|.||..||:|:.:
Mosquito   326 GLGNILVCLAVALDRKLQNVTNYFLLSLAIADLLVSLFVMPLGAIPGFL-GYWPFGVTWCNIYVT 389

  Fly   188 LDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGL-IAAVWICSSAISFPAIVWWRAA 251
            .|||..:||||::|.|||.||..|.:|.......| ||..|: ||.||:.:..:|....|.....
Mosquito   390 CDVLACSASILHMCFISLGRYLGIRNPLGSRHHST-KRLTGIKIALVWLLAMLVSSSITVLGMIN 453

  Fly   252 RDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYC-------------------RIYRA-- 295
            ::..||........:..:.||.|.::||:|:::||.||.                   .::|.
Mosquito   454 QNNIMPGPNECVINNRAFFVFGSLVAFYIPMVMMVVTYALTVQLLRKKARFLEQHPEGELFRRLG 518

  Fly   296 ---------------------AVIQTRSLKI-GTKQVL--------------MASGELQLTLRIH 324
                                 ..::.|...: ..||..              :|:|...|..|.|
Mosquito   519 GRLASSKHSNNSQSDGSSTSNKAVEMRKFTVNNNKQPAYGQHDSSPPSSLPSVAAGHSALPWRWH 583

  Fly   325 RGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTT------------TSTPE 377
              |||           .|.|.......|:..|.||.|..:.|.|..|.            |.||:
Mosquito   584 --GTT-----------AGTGKMDSRMSSIKGSMSHPHLGYSNGGNRTMAGKRSRTVCDQGTQTPD 635

  Fly   378 EPDDE----------------PLSALHNN----GLARHRHMGKNFSLSRKLAKFAKEKKAAKTLG 422
            ..:.|                |..|::.|    |..:..::..|        ..|.|:||.|.||
Mosquito   636 SIERETRRQKFCSFRIHLNSVPTPAINFNLKFLGSKKRTNLSAN--------AVATEQKATKVLG 692

  Fly   423 IVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVR 487
            :|...|:.||.|||::|::.....|....|.||| |..|||:::|.:||:||..:::.||.||:|
Mosquito   693 LVFFTFVFCWAPFFILNIIFAAWPEAKVPERIVS-ICLWLGYVSSTINPIIYTIFNKTFRAAFIR 756

  Fly   488 LLCMCCPRKIR-RKYQPTMRSK---SQCHVAAAMVAAS 521
            ||...|.|..| .:|:....|:   |.|..:|..:|.|
Mosquito   757 LLRCRCERSGRPPRYRSVTDSRGAISLCTPSALPLAIS 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	131/452 (29%)
		TM helix 2	143..169	CDD:320195	16/25 (64%)
		TM helix 3	182..212	CDD:320195	15/29 (52%)
		TM helix 4	224..246	CDD:320195	8/22 (36%)
		TM helix 5	266..295	CDD:320195	10/47 (21%)
		TM helix 6	297..442	CDD:320195	45/191 (24%)
		TM helix 7	453..478	CDD:320195	12/24 (50%)
5-HT2A	XP_061500179.1	None