Protein Alignment Dop1R2 and Adra2b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_033763.3
• Gene: Adra2b / 11552
• MGIID: 87935
• Length: 448
• Species: Mus musculus
• Alignment Length: 459
• Identity: 137/459 - (29%)
• Similarity: 202/459 - (44%)
• Gaps: 117/459 - (25%)

  Fly   112 LAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWF 176
            :.||.||   |:|||:||||||:..|.|....|.|:.|||.||.||..:::|||...|:| ..|:
Mouse    19 ITFLILF---TIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELL-GYWY 79

  Fly   177 FGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAIS 241
            |...||:::.:|||||.|:||::||.||||||||::....|..:.|.:|...:|..||:.::.||
Mouse    80 FWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVIS 144

  Fly   242 FPAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIG 306
            .|.:::....|.......:|...:...|::.||..||:.|.|:|:..|.|||   ||..||
Mouse   145 LPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIY---VIAKRS---- 202

  Fly   307 TKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGG-------GGGG-------------- 350
                             |..|.         |...|.|.|       ..||
Mouse   203 -----------------HCRGL---------GAKRGSGEGESKKPHPAAGGVPASAKVPTLVSPL 241

  Fly   351 GSLSHSHSHSHHHHHNHGG---------------------------GTTTSTPE---EPDDE--- 382
            .|:..::.|.........|                           ||:.:|.|   |.|:|
Mouse   242 SSVGEANGHPKPPREKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVE 306

  Fly   383 ----------PLSALH--------NNGLARHRH---MGKNFSLS-----RKLAKFAKEKKAAKTL 421
                      |.|..:        :..||..|.   :.||..::     |:..:.::||:....|
Mouse   307 ECEPQTLPASPASVFNPPLQQPQTSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVL 371

  Fly   422 GIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFV 486
            .:|:|||::||.|||....|...|.:..:....:.....|:|:.||.:|||||..:::||||||.
Mouse   372 AVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFR 436

  Fly   487 RLLC 490
            |:||
Mouse   437 RILC 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	128/442 (29%)
		TM helix 2	143..169	CDD:320195	12/25 (48%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	7/21 (33%)
		TM helix 5	266..295	CDD:320195	12/28 (43%)
		TM helix 6	297..442	CDD:320195	42/224 (19%)
		TM helix 7	453..478	CDD:320195	9/24 (38%)
Adra2b	NP_033763.3	TM helix 3	85..115	CDD:320444	19/29 (66%)
		TM helix 4	127..150	CDD:320444	7/22 (32%)
		TM helix 5	169..198	CDD:320444	12/31 (39%)
		TM helix 6	362..392	CDD:320444	12/29 (41%)
		TM helix 7	403..428	CDD:320444	9/24 (38%)
		7tmA_alpha2B_AR	7..435	CDD:320444	132/452 (29%)
		TM helix 1	14..40	CDD:320444	14/23 (61%)
		TM helix 2	47..73	CDD:320444	12/25 (48%)