Protein Alignment Dop1R2 and Adra1d

DIOPT Version :9

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_038488.4
• Gene: Adra1d / 11550
• MGIID: 106673
• Length: 562
• Species: Mus musculus
• Alignment Length: 598
• Identity: 196/598 - (32%)
• Similarity: 265/598 - (44%)
• Gaps: 160/598 - (26%)

  Fly    69 ATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEA------------------LPNDRVGLLAFL 115
            |......||...|:|.||.|     |.:.|...||                  :....||:..||
Mouse    38 AVGGVPGATGGSAVVGTGSG-----EDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFL 97

  Fly   116 FLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTD 180
            ..|....|.||.||||:|...|:|.|.|||||.:|||||.|:...|:||||..||| ..|.||..
Mouse    98 AAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVL-GFWAFGRT 161

  Fly   181 WCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAI 245
            :||:|.::|||..|||||:||.||:|||..:.....||..||.::||.::|.:|..:..:|...:
Mouse   162 FCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPL 226

  Fly   246 VWWRAARDGEMPAYK--CTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTK 308
            :.|:.    .:|..:  |..||.:||.:|||..|||||:.|:|..|||:|..|...||||:.|.|
Mouse   227 LGWKE----PVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIK 287

  Fly   309 QVLMASGELQLTLRIH-RGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTT 372
            :....:.|  :.|||| ||..|              ...|..|...|..|             |.
Mouse   288 REPGKASE--VVLRIHCRGAAT--------------SAKGNPGTQSSKGH-------------TL 323

  Fly   373 TSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFV 437
            .|                            |||.:|.||::||||||||.||:|||::||.|||.
Mouse   324 RS----------------------------SLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF 360

  Fly   438 VNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQ 502
            | |..|.....::..|.|..::.|||:.|||:||:||.|.||:|:|||:|||...|.|:.||.::
Mouse   361 V-LPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWR 424

  Fly   503 PTMRSKSQCHVAAAMVAASTSFGYHSVNQIDRTLMXRQLSSCSTCSGGSNCGGS----------- 556
                                .:|:|              ...||....|:|..|
Mouse   425 --------------------VYGHH--------------WRASTGDPRSDCAPSPRIAPPGAPLA 455

  Fly   557 RSAH----------HQHHSSGTATPSSS----------QRSCTRCQ---SFHRHHHRS---RRRS 595
            .:||          .|...||...|:|:          ||..|:.:   |...|..||   ||..
Mouse   456 LTAHPGPGSVDTPEAQASVSGRRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAE 520

  Fly   596 SGMQMRGDYNSTT 608
            :...:|.:..:.:
Mouse   521 TACALRSEVEAVS 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	81/173 (47%)
		7tm_1	125..474	CDD:278431	138/351 (39%)
Adra1d	NP_038488.4	7tm_GPCRs	91..407	CDD:333717	151/378 (40%)
		TM helix 1	93..117	CDD:320095	11/23 (48%)
		TM helix 2	126..148	CDD:320095	13/21 (62%)
		TM helix 3	164..186	CDD:320095	13/21 (62%)
		TM helix 4	209..225	CDD:320095	3/15 (20%)
		TM helix 5	246..269	CDD:320095	12/22 (55%)
		TM helix 6	338..363	CDD:320095	18/25 (72%)
		TM helix 7	375..400	CDD:320095	13/24 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BB8F
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001183
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910