Protein Alignment Dop1R2 and htr2c

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_017951833.1
• Gene: htr2c / 100496012
• XenbaseID: XB-GENE-967634
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 480
• Identity: 149/480 - (31%)
• Similarity: 230/480 - (47%)
• Gaps: 87/480 - (18%)

  Fly    49 SEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLA 113
            |.|:.|: ||| .:..:..|.|.:.:..|.:||        ..:.|..||.  |:|.:.....|.
 Frog    21 SVDISFH-NGL-MAWHVNNNVTLNQSMPTSAPA--------NASEEEKLSH--ESLADKNWSALL 73

  Fly   114 FLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFG 178
            .|.:. ..|:.||.|||:||..|:.|..|||:|:.||||||.|||::|||.|.:..:.:..|...
 Frog    74 TLIII-ILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLVTILYDYAWPLP 137

  Fly   179 TDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFP 243
            ...|.||.|||||||||||::||.||||||.||.:|..:....:..:|...|||||..|..||.|
 Frog   138 RKLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMP 202

  Fly   244 AIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTK 308
            ..|..............|...:. .:::..|.::|::||::||||||.               |.
 Frog   203 VPVIGLQDDSRVFVNSSCVLNDE-NFVLLGSFVAFFIPLIIMVFTYCL---------------TI 251

  Fly   309 QVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTT 373
            |||    :.|.|:.::. ...:.:::.|:
 Frog   252 QVL----QKQATVFMYE-EVPKQRRSSVN------------------------------------ 275

  Fly   374 STPEEPDDEPLSALHNNGLARHRH--MGKNFSLSRK--LAKFAKEKKAAKTLGIVMGVFIICWLP 434
            ...:|.:.|.:|.:.|:..|.|.:  :.|..:|.||  :.....|::|:|.||||..:|:|.|.|
 Frog   276 CLKKENNTENISMIQNHEAASHLNSPINKEGALFRKGTMQSINNERRASKVLGIVFFLFLIMWCP 340

  Fly   435 FFVVNLLSGFCIECIEHEEIVSA--IVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKI 497
            ||:.|::|..|.|..::|.:|..  :..|:|:::|.:||::|..::|.:||||...        |
 Frog   341 FFITNIMSVLCKEACDNELMVELLNVFVWVGYVSSGINPLVYTLFNRTYRRAFASY--------I 397

  Fly   498 RRKY---QPTMRSKSQCHVAAAMVA 519
            |.:|   :.||..::||...|...|
 Frog   398 RCQYYNSKKTMLQQNQCQHNATSTA 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	120/368 (33%)
		TM helix 2	143..169	CDD:320195	16/25 (64%)
		TM helix 3	182..212	CDD:320195	23/29 (79%)
		TM helix 4	224..246	CDD:320195	10/21 (48%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	31/148 (21%)
		TM helix 7	453..478	CDD:320195	7/26 (27%)
htr2c	XP_017951833.1	7tmA_5-HT2C	68..399	CDD:341346	125/396 (32%)
		TM helix 1	69..95	CDD:341346	10/26 (38%)
		TM helix 2	102..128	CDD:341346	16/25 (64%)
		TM helix 3	141..171	CDD:341346	23/29 (79%)
		TM helix 4	183..206	CDD:341346	10/22 (45%)
		TM helix 5	224..253	CDD:341346	11/44 (25%)
		TM helix 6	318..348	CDD:341346	14/29 (48%)
		TM helix 7	361..386	CDD:341346	7/24 (29%)