DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R2 and htr1d

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_002938881.3	Gene:	htr1d / 100494760	XenbaseID:	XB-GENE-992184	Length:	376	Species:	Xenopus tropicalis

Alignment Length:	386	Identity:	140/386 - (36%)
Similarity:	202/386 - (52%)	Gaps:	56/386 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 RVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLE 172
            ::.|...|.:.:.||:..|..||:.::..|.|||..||.|.|||..|.||.::|||.|..|.| .
Frog    37 KIALAVLLSIITLATLLSNVFVIITIVMTRKLHTPANYLIGSLAFTDLLVSILVMPISIAYTV-T 100

  Fly   173 NTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICS 237
            :||.||...||||...|:...|||||:||||:|||||||||...|....|.:|||.:|..|||.|
Frog   101 HTWTFGQIVCDIWLLSDITCCTASILHLCVIALDRYWAITDALEYTKHRTARRAAVMILVVWIIS 165

  Fly   238 SAISFPAIVWWRAARDGEMPAYKCTF-TEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTR 301
            ..||.|.:.|.:|....|:..  ||. |:.:.|.::|:..:||:|.::::..|.:||.||  ::|
Frog   166 ICISIPPLFWRQAKAHEELTV--CTINTDQISYTIYSTCGAFYIPTVLLILLYGKIYIAA--RSR 226

  Fly   302 SLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHN 366
            .||..:     ..|:...|.::..|.|                      ||...|.:.:.|..|.
Frog   227 ILKPPS-----IYGKRFTTAQLITGST----------------------GSSFCSINANVHMEHP 264

  Fly   367 HGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFS---LSRKLAKFAKEKKAAKTLGIVMGVF 428
            |    |:.||                ....|:....:   :.||....|:||||.|||||::|.|
Frog   265 H----TSETP----------------VCINHIKIKLADSIIERKRLSAAREKKATKTLGIILGAF 309

  Fly   429 IICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            |:||||||||:|:...|.:....:.::....||||::||.:|||||..::.||::||.:|:
Frog   310 IVCWLPFFVVSLVLPICRDACWFDPLLFDFFTWLGYLNSLINPVIYTVFNEDFKKAFQKLI 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	76/172 (44%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	129/352 (37%)
htr1d	XP_002938881.3	7tmA_5-HT1B_1D	34..366	CDD:320455	137/380 (36%)
		TM helix 1	40..64	CDD:320455	7/23 (30%)
		TM helix 2	73..95	CDD:320455	12/21 (57%)
		TM helix 3	111..133	CDD:320455	13/21 (62%)
		TM helix 4	156..172	CDD:320455	7/15 (47%)
		TM helix 5	194..217	CDD:320455	5/22 (23%)
		TM helix 6	299..321	CDD:320455	16/21 (76%)
		TM helix 7	334..359	CDD:320455	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000