Protein Alignment Dop1R2 and hrh4.b2

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_031760447.1
• Gene: hrh4.b2 / 100485915
• XenbaseID: XB-GENE-22168371
• Length: 390
• Species: Xenopus tropicalis
• Alignment Length: 452
• Identity: 115/452 - (25%)
• Similarity: 193/452 - (42%)
• Gaps: 103/452 - (22%)

  Fly    72 SATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRE 136
            |..:.||..|       |:||      :|.:|:   .:.::|.:.|....||.||:|||||...|
 Frog    10 SGINLTLDTA-------GSTT------QFSDAV---NILIIALISLLILLTVGGNTLVILAFFVE 58

  Fly   137 RYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLC 201
            :.|...:|:|:.:|::||.::|...:|....| :|...|..|...|.:|..:|....|||..|:.
 Frog    59 KRLRNQSNFFLLNLSIADFILGTFAIPLYVPY-LLTGKWLLGKFLCKLWLIVDYTMCTASAFNVA 122

  Fly   202 VISLDRYWAITDPFSY------PMRMTVKRAAGLIAAVWICSSAISFPAIVWWR-AARDGEMPAY 259
            :||.||:.::|....|      |.|..:|     :|||||.|..:..|||::|. .....|:|..
 Frog   123 LISWDRFLSVTQAVLYRSQQNRPCRTVIK-----MAAVWILSFLLYGPAIIFWDFVPSTEEIPEN 182

  Fly   260 KCT----FTEHLGYLVFSSTISFYLPLLVMVF----TYCRIYRAAVIQTRSLKIGTKQVLMASGE 316
            .|.    :|.:  ||:.:|...|.|||:.:.|    .||.|.:.
 Frog   183 ICVAGFYYTWY--YLLTASAFDFVLPLISISFFNLSIYCNIKKR--------------------- 224

  Fly   317 LQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDD 381
                       :.|..||.:               ||....|.............|..:|:....
 Frog   225 -----------SRRKMQNSI---------------SLPPQKSRKEAKLCTIATNITLQSPQIDIQ 263

  Fly   382 EP-------LSALHNNGLARHRHMGKNFSL-SRKLAKFAKEKKAAKTLGIVMGVFIICWLPF-FV 437
            :.       :|.....|:....|..|.... :.:::..:::||.||:|.:::.:|.|||.|: |:
 Frog   264 KKSFRRRINISCNQCFGIKSSSHNNKRSDRENNQVSDLSRDKKVAKSLSVLVCIFAICWAPYSFL 328

  Fly   438 VNLLS---GFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRK 496
            :::.:   |:||....::     |..||.|.||.:||:||....:.|::||:.::...|.:|
 Frog   329 MSIRAACHGYCIHIYWYD-----ITFWLLWTNSAINPIIYPLCHKGFQKAFLNIVKYVCMKK 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	100/389 (26%)
		TM helix 2	143..169	CDD:320195	7/25 (28%)
		TM helix 3	182..212	CDD:320195	11/29 (38%)
		TM helix 4	224..246	CDD:320195	9/21 (43%)
		TM helix 5	266..295	CDD:320195	11/32 (34%)
		TM helix 6	297..442	CDD:320195	23/153 (15%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
hrh4.b2	XP_031760447.1	7tmA_Histamine_H3R_H4R	44..374	CDD:320176	100/389 (26%)
		TM helix 2	65..92	CDD:320176	8/27 (30%)
		TM helix 3	103..133	CDD:320176	11/29 (38%)
		TM helix 4	148..166	CDD:320176	7/22 (32%)
		TM helix 5	191..221	CDD:320176	11/31 (35%)
		TM helix 6	302..332	CDD:320176	11/29 (38%)
		TM helix 7	342..367	CDD:320176	10/29 (34%)