DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R2 and htr1e

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_002933964.1	Gene:	htr1e / 100380026	XenbaseID:	XB-GENE-965113	Length:	362	Species:	Xenopus tropicalis

Alignment Length:	376	Identity:	129/376 - (34%)
Similarity:	192/376 - (51%)	Gaps:	46/376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGT 179
            |.:.:..|...||.||||:...:.||...||.|.||||.|.||.::|||.|..|.|:: ||..|.
Frog    26 LAIITILTTVLNSAVILAICTTKKLHQPANYLICSLAVTDFLVAILVMPLSITYIVMD-TWTLGY 89

  Fly   180 DWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPA 244
            ..|:||.|:|:...|.|||:||||:|||||||||...|..:.|||||..:|..||..|..||.|.
Frog    90 VICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTVKRAGIMILTVWTISVFISIPP 154

  Fly   245 IVWWRAARDGEMPAYKCTFT-EHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTK 308
            : :||...:..:|: ||... :||.|.::|:..:||:||.:::..|.|||.||           |
Frog   155 L-FWRNHHNINIPS-KCIIQHDHLIYTIYSTCGAFYIPLTLILILYYRIYHAA-----------K 206

  Fly   309 QVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTT 373
            .:....|..:     |....:.|.||                 |.:|.................|
Frog   207 NLYQKRGSSR-----HLSNRSNDSQN-----------------SFAHCKLTQTFCVSEFSTSDPT 249

  Fly   374 STPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVV 438
            :..|:.:....:..::|.:.......:..|.||       |:|||:.||:::|.||:.|||||:.
Frog   250 TEFEKMNASVRTPPYDNDIDIFGDRQQQISSSR-------ERKAARILGLILGAFILSWLPFFIK 307

  Fly   439 NLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489
            .|:.|..:..:..|  |:..:||||::||.:||::|..::.||:.||.:|:
Frog   308 ELVVGIQLCTVSPE--VADFLTWLGYVNSLVNPLLYTSFNDDFKLAFKKLI 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	79/172 (46%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	121/349 (35%)
htr1e	XP_002933964.1	7tmA_5-HT1E	20..352	CDD:320457	126/370 (34%)
		TM helix 1	21..47	CDD:320457	8/20 (40%)
		TM helix 2	54..80	CDD:320457	14/25 (56%)
		TM helix 3	92..122	CDD:320457	19/29 (66%)
		TM helix 4	134..156	CDD:320457	10/22 (45%)
		TM helix 5	175..204	CDD:320457	12/28 (43%)
		TM helix 6	281..311	CDD:320457	17/36 (47%)
		TM helix 7	320..345	CDD:320457	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910