DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7568 and PRPF4

DIOPT Version :9

Sequence 1:NP_001263071.1 Gene:CG7568 / 43482 FlyBaseID:FBgn0039673 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_004688.2 Gene:PRPF4 / 9128 HGNCID:17349 Length:522 Species:Homo sapiens


Alignment Length:491 Identity:126/491 - (25%)
Similarity:210/491 - (42%) Gaps:82/491 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 GNERLRHFDLLDLDSKTNIEPLADRILLQTLAEAEEEQSPADLEKSPPPRPVSGSV--------- 79
            ||..:...::.:::     |.:::| ..:.|||.|..:....:..|.....|...:         
Human    63 GNINITSGEVFEIE-----EHISER-QAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITL 121

  Fly    80 ---------ARSQNAFSAL-KQALEKLQ------KKLREPVKKKFYLHKCHNS---HILPLTNVS 125
                     .|.:|..|.: ..||:|.:      ||.:|..::.:| |:..||   ..|.:.|.|
Human   122 FGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWY-HEGPNSLKVARLWIANYS 185

  Fly   126 FDRSGERC----LTGSYDRTCHVINTQTAQVEHI---LSGHDNVVFSVGFNFP----HWLVYLQS 179
            ..|:.:|.    |......|     |:|:|::.:   |...:|....:|.:.|    |:      
Human   186 LPRAMKRLEEARLHKEIPET-----TRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHF------ 239

  Fly   180 GGSGNNLTTFSIIFSDKIVTGSFDGTAKVWSATSGQSLCTFYGHTAELVAAEFHP-----VDGK- 238
              |.|         |..:.|..:.|..|:||......|.|..||...:.|..|||     :|.| 
Human   240 --SPN---------SKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293

  Fly   239 -SIATASLDGSARIYDVETSHELQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRS-KSL 301
             ::|:.:.|||.:::.:::...:..:..|...|....::..|:.|.|..:|.|..:||:.: :.:
Human   294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358

  Fly   302 GHQLRGHSAELSNCVWNFSGSLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQL 366
            .|| .|||..:.:..::..|||..||.||...|:||.|.....::|.. |..|:..::|...|..
Human   359 LHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG-HLKEIYGINFSPNGYH 421

  Fly   367 LATCSSDCTARVWRLEGSSELEMLSLMAGHSDEVSKVCFSP-SGCMLLTASADNTARLWLTESGQ 430
            :||.|.|.|.:||.|.   :...:..:..|.:.|:.|.|.| .|..|||.:.||||::|......
Human   422 IATGSGDNTCKVWDLR---QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWS 483

  Fly   431 CSQVLAGHEGEVFSCAYSYAGDAILTASKDNSCRFW 466
            ..:.||||||:|.....|..|..|.|.|.|.:.:.|
Human   484 PLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7568NP_001263071.1 WD40 93..466 CDD:225201 111/401 (28%)
WD40 repeat 122..158 CDD:293791 10/42 (24%)
WD40 154..467 CDD:238121 93/329 (28%)
WD40 repeat 189..222 CDD:293791 8/32 (25%)
WD40 repeat 228..265 CDD:293791 10/43 (23%)
WD40 repeat 270..306 CDD:293791 10/36 (28%)
WD40 repeat 314..348 CDD:293791 11/33 (33%)
WD40 repeat 355..393 CDD:293791 10/37 (27%)
WD40 repeat 400..436 CDD:293791 13/36 (36%)
WD40 repeat 442..466 CDD:293791 7/23 (30%)
PRPF4NP_004688.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SFM 103..141 CDD:128776 4/37 (11%)
WD 1 229..268 12/55 (22%)
WD40 233..519 CDD:238121 89/307 (29%)
WD40 repeat 234..271 CDD:293791 11/53 (21%)
WD 2 271..318 12/46 (26%)
WD40 repeat 285..321 CDD:293791 6/35 (17%)
WD 3 321..360 9/38 (24%)
WD40 repeat 326..362 CDD:293791 10/36 (28%)
WD 4 363..402 14/38 (37%)
WD40 repeat 369..404 CDD:293791 11/34 (32%)
WD 5 405..444 12/42 (29%)
WD40 repeat 410..444 CDD:293791 10/36 (28%)
WD 6 447..487 14/39 (36%)
WD40 repeat 452..489 CDD:293791 13/36 (36%)
WD 7 490..521 12/30 (40%)
WD40 repeat 495..519 CDD:293791 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0272
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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