DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7568 and PRP4

DIOPT Version :9

Sequence 1:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_015504.1	Gene:	PRP4 / 856307	SGDID:	S000006382	Length:	465	Species:	Saccharomyces cerevisiae

Alignment Length:	419	Identity:	108/419 - (25%)
Similarity:	186/419 - (44%)	Gaps:	63/419 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DLLDLDSKTNIEPLADRILLQTLAEAEEEQ-----SPADLEKSPPPR-PVSGSVARSQNAFSALK 90
            |.:||::..|:|.:...       |.:||.     :||..|.....| .::.|:.||:   ..|:
Yeast    83 DEIDLENINNMENINGE-------EVDEEDDEDFFTPATSELIFARRFLINYSLERSR---KRLQ 137

  Fly    91 QALEKLQK--KLREPVKKKFYLHKCHNSHIL--------PLTNVSFDRSGERCLTGSYDRTCHVI 145
            :.:|:.||  ..:|.:.::..|.:..|..:.        |::.||.........|||:.....|:
Yeast   138 KEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVL 202

  Fly   146 NTQTAQ-VEHILSGHDNVVFSVGFNFPHWLVYLQSGGSGNNLTTFSIIFSDKIVTGSFDGTAKVW 209
            |:||.| :...|..|...:.::.::           ...||          ::::.:.||..|.:
Yeast   203 NSQTLQPLTQKLDSHVGKIGAIDWH-----------PDSNN----------QMISCAEDGLIKNF 246

  Fly   210 SATSGQS----LCTFYGHTAELVAAEFHPVDGKSIATASLDGSARIYDVETSHELQQLTHHGAEV 270
            ..::.:.    |....||...:...::|| .||.|.:||.|.:.|::|..|..||.....|...|
Yeast   247 QYSNEEGGLRLLGDLVGHERRISDVKYHP-SGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGV 310

  Fly   271 IAARFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQLRGHSAELSNCVWNFSGSLIATGSLDNTARI 335
            .:..|..||.::.:|..|..:.:||:||.|....|.|||..:....|:.:|..:|||..|....:
Yeast   311 FSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINV 375

  Fly   336 WDTRKLDQ-ELYLAARHSDEVLDVSF--DAAGQLLATCSSDCTARVWRLEGSSE--LEMLSLMAG 395
            ||.||.|: :|.....|.:.|..|.|  :..|:.|.:|..|....|:    ||:  |:|.|| ||
Yeast   376 WDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVY----SSDTWLKMGSL-AG 435

  Fly   396 HSDEVSKVCFSPSGCMLLTASADNTARLW 424
            |:|::..:..|.:...|::...|.:.:||
Yeast   436 HTDKIISLDISNNSHFLVSGGWDRSIKLW 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	92/352 (26%)
		WD40 repeat	122..158	CDD:293791	11/36 (31%)
		WD40	154..467	CDD:238121	75/280 (27%)
		WD40 repeat	189..222	CDD:293791	4/36 (11%)
		WD40 repeat	228..265	CDD:293791	13/36 (36%)
		WD40 repeat	270..306	CDD:293791	11/35 (31%)
		WD40 repeat	314..348	CDD:293791	12/34 (35%)
		WD40 repeat	355..393	CDD:293791	13/41 (32%)
		WD40 repeat	400..436	CDD:293791	5/25 (20%)
		WD40 repeat	442..466	CDD:293791
PRP4	NP_015504.1	HIP1_clath_bdg	128..175	CDD:406822	10/49 (20%)
		WD40	175..465	CDD:238121	86/317 (27%)
		WD40 repeat	178..216	CDD:293791	11/37 (30%)
		WD40 repeat	222..263	CDD:293791	6/61 (10%)
		WD40 repeat	268..304	CDD:293791	13/36 (36%)
		WD40 repeat	311..346	CDD:293791	10/34 (29%)
		WD40 repeat	352..387	CDD:293791	11/34 (32%)
		WD40 repeat	396..434	CDD:293791	14/42 (33%)
		WD40 repeat	440..464	CDD:293791	3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900